Itanium (/aɪˈteɪniəm/; eye-TAY-nee-əm) is a discontinued family of 64-bit Intel microprocessors that implement the Intel Itanium architecture (formerly called IA-64). The Itanium architecture originated at Hewlett-Packard (HP), and was later jointly developed by HP and Intel. Launching in June 2001, Intel initially marketed the processors for enterprise servers and high-performance computing systems. In the concept phase, engineers said "we could run circles around PowerPC...we could kill the x86". Early predictions were that IA-64 would expand to the lower-end servers, supplanting Xeon, and eventually penetrate into the personal computers, eventually to supplant reduced instruction set computing (RISC) and complex instruction set computing (CISC) architectures for all general-purpose applications.

When first released in 2001 after a decade of development, Itanium's performance was disappointing compared to better-established RISC and CISC processors. Emulation to run existing x86 applications and operating systems was particularly poor. Itanium-based systems were produced by HP and its successor Hewlett Packard Enterprise (HPE) as the Integrity Servers line, and by several other manufacturers. In 2008, Itanium was the fourth-most deployed microprocessor architecture for enterprise-class systems, behind x86-64, Power ISA, and SPARC.^{[needs update]}

In February 2017, Intel released the final generation, Kittson, to test customers, and in May began shipping in volume. It was only used in mission-critical servers from HPE.

In 2019, Intel announced that new orders for Itanium would be accepted until January 30, 2020, and shipments would cease by July 29, 2021. This took place on schedule.

Itanium never sold well outside enterprise servers and high-performance computing systems, and the architecture was ultimately supplanted by competitor AMD's x86-64 (also called AMD64) architecture. x86-64 is a compatible extension to the 32-bit x86 architecture, implemented by, for example, Intel's own Xeon line and AMD's Opteron line. By 2009, most servers were being shipped with x86-64 processors, and they dominate the low cost desktop and laptop markets which were not initially targeted by Itanium. In an article titled "Intel's Itanium is finally dead: The Itanic sunken by the x86 juggernaut" Techspot declared "Itanium's promise ended up sunken by a lack of legacy 32-bit support and difficulties in working with the architecture for writing and maintaining software", while the dream of a single dominant ISA would be realized by the AMD64 extensions.

In 1989, HP started to research an architecture that would exceed the expected limits of the reduced instruction set computer (RISC) architectures caused by the great increase in complexity needed for executing multiple instructions per cycle due to the need for dynamic dependency checking and precise exception handling. HP hired Bob Rau of Cydrome and Josh Fisher of Multiflow, the pioneers of very long instruction word (VLIW) computing. One VLIW instruction word can contain several independent instructions, which can be executed in parallel without having to evaluate them for independence. A compiler must attempt to find valid combinations of instructions that can be executed at the same time, effectively performing the instruction scheduling that conventional superscalar processors must do in hardware at runtime.

HP researchers modified the classic VLIW into a new type of architecture, later named Explicitly Parallel Instruction Computing (EPIC), which differs by: having template bits which show which instructions are independent inside and between the bundles of three instructions, which enables the explicitly parallel execution of multiple bundles and increasing the processors' issue width without the need to recompile; by predication of instructions to reduce the need for branches; and by full interlocking to eliminate the delay slots. In EPIC the assignment of execution units to instructions and the timing of their issuing can be decided by hardware, unlike in the classic VLIW. HP intended to use these features in PA-WideWord, the planned successor to their PA-RISC ISA. EPIC was intended to provide the best balance between the efficient use of silicon area and electricity, and general-purpose flexibility. In 1993 HP held an internal competition to design the best (simulated) microarchitectures of a RISC and an EPIC type, led by Jerry Huck and Rajiv Gupta respectively. The EPIC team won, with over double the simulated performance of the RISC competitor.

At the same time Intel was also looking for ways to make better ISAs. In 1989 Intel had launched the i860, which it marketed for workstations, servers, and iPSC and Paragon supercomputers. It differed from other RISCs by being able to switch between the normal single instruction per cycle mode, and a mode where pairs of instructions are explicitly defined as parallel so as to execute them in the same cycle without having to do dependency checking. Another distinguishing feature were the instructions for an exposed floating-point pipeline, that enabled the tripling of throughput compared to the conventional floating-point instructions. Both of these features were left largely unused because compilers didn't support them, a problem that later challenged Itanium too. Without them, i860's parallelism (and thus performance) was no better than other RISCs, so it failed in the market. Itanium would adopt a more flexible form of explicit parallelism than i860 had.