Budwig began experimenting with flaxseed oil and quark, observing their potential benefits for cell oxygenation and overall health. She claimed that this combination could restore the electrical charge of cell membranes, improving their function.

Over the decades, Budwig refined her protocol, emphasizing the importance of whole, unprocessed foods, sunlight, and emotional well-being alongside the flaxseed oil and quark mixture. She treated patients with various illnesses, particularly cancer, at her private clinic.

Budwig published her most well-known book, which outlined her theories on cancer, her treatment protocol, and her views on conventional cancer therapies. This book brought her method to a wider audience but also fueled further controversy.

Budwig traveled extensively, giving lectures and workshops on her protocol. She also offered consultations to individuals seeking alternative cancer treatments. Her work attracted both fervent supporters and staunch critics.