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Joseph Lister

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Joseph Lister

Joseph Lister, 1st Baron Lister, OM, PC, FRS, FRCSE, FRCPGlas, FRCS (5 April 1827 – 10 February 1912) was a British surgeon, medical scientist, experimental pathologist and pioneer of antiseptic surgery and preventive healthcare. Lister revolutionised the craft of surgery by the use of close anatomical observation, in the same manner that John Hunter revolutionised the science of surgery.

From a technical viewpoint, Lister was not an exceptional surgeon, but his research into bacteriology and infection in wounds revolutionised surgery throughout the world.

Lister's contributions were four-fold. Firstly, as a surgeon at the Glasgow Royal Infirmary, he introduced carbolic acid (modern-day phenol) as a steriliser for surgical instruments, patients' skins, sutures, surgeons' hands, and wards, promoting the principle of antiseptics. Secondly, he researched the role of inflammation and tissue perfusion in the healing of wounds. Thirdly, he advanced diagnostic science by analyzing specimens using microscopes. Fourthly, he devised strategies to increase the chances of survival after surgery. His most important contribution, however, was recognising that putrefaction in wounds is caused by germs, in connection to Louis Pasteur's then-novel germ theory of fermentation.

Lister's work led to a reduction in post-operative infections and made surgery safer for patients, leading to him being distinguished as the "father of modern surgery".

Lister was born to a prosperous, educated Quaker family in the village of Upton, then near but now in London, England. He was the fourth child and second son of four sons and three daughters born to gentleman scientist and wine merchant Joseph Jackson Lister and school assistant Isabella Lister née Harris. The couple married in a ceremony held in Ackworth, West Yorkshire on 14 July 1818.

Lister's paternal great-great-grandfather, Thomas Lister was the last of several generations of farmers who lived in Bingley in West Yorkshire. Lister joined the Society of Friends as a young man and passed his beliefs on to his son, Joseph Lister. He moved to London in 1720 to open a tobacconist's shop in Aldersgate Street in the City of London. His son, John Lister, was born there. Lister's grandfather was apprenticed to watchmaker Isaac Rogers, in 1752 and followed that trade on his own account in Bell Alley, Lombard Street from 1759 to 1766. He then took over his father's tobacco business, but gave it up in 1769 in favour of working at his father-in-law Stephen Jackson's business as a wine-merchant at No 28 Old Wine and Brandy Values on Lothbury Street, opposite Tokenhouse Yard.

His father was a pioneer in the design of achromatic object lenses for use in compound microscopes He spent 30 years perfecting the microscope, and in the process, discovered the Law of Aplanatic Foci, building a microscope where the image point of one lens coincided with the focal point of another. Up until that time, the best higher magnification lenses produced an excessive secondary aberration known as a coma, which interfered with normal use. It was considered a major advance that elevated histology into an independent science. By 1832, Lister's work had built a reputation sufficient to enable his being elected to the Royal Society. His mother, Isabella, was the youngest daughter of master mariner Anthony Harris. Isabella worked at the Ackworth School, a Quaker school for the poor, assisting her widowed mother, the superintendent of the school.

The eldest daughter of the couple was Mary Lister. On 21 August 1851, she married the barrister Rickman Godlee of Lincoln's Inn and the Middle Temple, who belonged to the Friends meeting house in Plaistow. The couple had six children. Their second child was Rickman Godlee, a neurosurgeon who became Professor of Clinical Surgery at the University College Hospital and surgeon to Queen Victoria. He became Lister's biographer in 1917. The eldest son of Joseph and Isabella Lister was John Lister, who died of a painful brain tumour. With John's death, Joseph became the heir of the family. The couple's second daughter was Isabella Sophia Lister, who married Irish Quaker Thomas Pim in 1848. Lister's other brother William Henry Lister died after a long illness. The youngest son was Arthur Lister, a wine merchant, botanist and lifelong Quaker, who studied Mycetozoa. He worked alongside his daughter Gulielma Lister to produce the standard monograph on Mycetozoa. By 1898, Lister's work had built a reputation sufficient to enable his election to the Royal Society. Gulielma Lister, a talented artist, later updated the standard monograph with colour drawings. Her work built a reputation sufficient to be elected a fellow of the Linnean Society in 1904. She became its vice-president in 1929. The couple's last child was Jane Lister; she married widower Smith Harrison, a wholesale tea merchant.

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