List of General Hospital characters introduced in the 1990s

General Hospital is the longest-running American television serial drama, airing on ABC. Created by Frank and Doris Hursley, it originally was set it in a general hospital (hence the title), in an unnamed fictional city. In the 1970s, the city was named Port Charles, New York. The series premiered on April 1, 1963. This is a list of notable characters who significantly impacted storylines and began their run from 1990 to 1999.

Brook Lynn Ashton (also Quartermaine) is a fictional character on the ABC soap opera General Hospital. On the series, she is the daughter of Ned Quartermaine and Lois Cerullo, and was named after her mother's hometown of Brooklyn.

Originally played by actress child actors Katlyn & Sarah Avery in 1997, Brooke Radding from 1999 to 2001, the character was later recast with actress Adrianne León in 2004, who was nominated for two awards for the role in 2005: the Soap Opera Digest "Outstanding Female Newcomer Award", and "Outstanding Younger Actress" in the Daytime Emmy Awards. Leon continued to play the character until 2006. It was announced in 2010 that León would return to the show as Brook Lynn that May. She left the series again in 2011 after the character was written off.

In November 2019, TVLine announced Amanda Setton had been cast in the role; she made her first appearance on November 18. Jamey Giddens of Daytime Confidential had suggested that Setton take over the role in 2012, one year after León was written off. General Hospital executive producer Frank Valentini, who was also Setton's boss at One Life to Live, hired Setton to play the role without an audition process, replacing León. In August 2020, it was announced Setton would take temporary leave from the role to take a maternity leave; actress Briana Lane was cast in the role. Lane assumed the role from August 6 to November 16, 2020. Lane's performance in the role garnered her a Daytime Emmy Award nominations for Outstanding Guest Performer in a Drama Series in 2021. In February 2021, it was announced Setton would return to the role; she returned during the March 15 episode.

Brook Lynn is raised by her mother after her parents' divorce, but lives with her father as a teenager. She is a talented songwriter and singer, and her mother, a band manager and record-company executive, often pressures her to pursue a singing career. Brook dates Diego Alcazar for a time, but they later break up. She is also involved in adventures with Georgie Jones, her uncle Dillon Quartermaine, and Sage Alcazar, who competes with her for a recording contract. The obnoxious Sage is murdered by serial killer Mary Bishop after she is locked in the Quartermaine freezer by a fed-up Georgie. Sage is a sitting duck for the killer, who mistakes her for Brook's adopted cousin Emily Quartermaine. After her death, Brook puts a poignant song written by Sage to music and records it. Sage's uncle Lorenzo Alcazar blames Brook and the other teens for her death, but is brought to tears when he hears Brook perform the song. The following year, Brook is a victim of the Port Charles Stalker, who drugs girls and takes pictures of them. The stalker later turns out to be Sage's cousin Diego, who had read her journals and decided to get revenge on Brook and the others on Sage's behalf. Soon after, Brook decided to leave Port Charles and return to New York to pursue her music career.

Brook Lynn was convinced to return to town in 2010 by Carly Corinthos Jacks, who promised to pay Brook if she came between Dante Falconeri, with whom Brook grew up in Bensonhurst, and his girlfriend, Lulu Spencer. Carly hired Brook Lynn to sing at the Metro Court, and purchased her an apartment across from Dante's. Brook succeeds in drugging Dante at a bar, and attempts to have sex with him in his apartment, but Lulu arrives to stop this and blames Brook entirely. Feeling guilty, Brook later tells Lulu that she had been working for Carly, but Carly lies and claims she was only trying to test Dante to see if he was worthy of Lulu. Lulu believes Carly, and continues to blame Brook. Finding Brook in a state of devastation, wealthy Nikolas Cassadine invites her into his castle and hires her to be his escort for a formal dinner in France. While he teaches her etiquette, the two begin a flirtation, and then a romance. Brook eventually moves into the Cassadine castle and continues to work as Nikolas' escort at formal events. She is soon at odds with Elizabeth Webber, the mother of Nikolas' son Aiden. Elizabeth was interested in pursuing a relationship with Nikolas after previously turning him down, but Nikolas was now interested in Brook Lynn, and turned her down. Brook Lynn later got an offer to go on tour with a band. Nikolas got caught up in family issues, and encouraged Brook Lynn to take the offer because he could not put her first. The two parted ways, and Brook Lynn left town.

Brook Lynn returned to town in 2019 with Setton taking over the role. Brook Lynn legally changed her last name to Quartermaine in early 2020. Unlike León, Setton can't sing and is not a musician in real life, so in September 2020, Brook Lynn's singing career ended when her throat was slashed by Nelle Benson, nearly killing her.

Tom Baker, portrayed by Jay Lacopo, first appeared on November 2, 1998. On November 15, 2016, Don Harvey assumed the role.