Khreshchatyk (Ukrainian: Хрещатик, pronounced [xreˈʃtʃɑtɪk]) is the main street of Kyiv, the capital city of Ukraine. The street is 1.2 kilometres (0.75 mi) long, and runs in a northeast-southwest direction from European Square through the Maidan to Bessarabska Square and the Besarabsky Market. The offices of the Kyiv City Council, the Post Office, the Ministry of Agrarian Policy and Food, the State Committee of Television and Radio Broadcasting, the TsUM department store, and the Ukrainian House, are all located on Khreshchatyk.

Khreshchatyk was deliberately destroyed during World War II by retreating Red Army troops. Among the notable buildings that were dynamited were the Kyiv City Duma, the Kyiv Stock Exchange, the National Hotel [uk], and the Ginsburg Skyscraper. The street was rebuilt in a Stalinist neo-classical style after the end of the war, and has been renovated since Ukraine's independence.

The area of Kyiv now occupied by Khreshchatyk was originally a forest-covered valley with a stream flowing through it. In ancient times, it was a hunting place where Kyiv residents hung out nets to catch wild animals,which gave the ancient name of the area, Perevesishte. The name Khreshchatyk is believed to be derived from the Slavic word krest or khrest (cross), as it lies in a valley that is crossed by several ravines. A small river, the Khreshchatyk River, a tributary of the Lybid River, ran along much of the valley. A road ran beside the stream.

In 1770, the doctor and diarist John Lerche described the landscape: "At the end of the Pechersk suburb, there is a narrow road (Khreshchatytskaya) due to a deep gulley or valley; but it cannot be avoided, because it connects all three cities."

In Kievan Rus' times, the fortifications of the Upper Town existed across Old Kyiv Hill [uk] above the ravine. These had been reduced to ruins by the early 19th century, when they were removed, leaving a square at the foot the hill at the modern Maidan Nezalezhnosti. Construction of the street started at the end of the 18th century, when the ravine began to be filled in. The first houses, built in 1797, were wooden, with the earliest recorded building being the late 18th-century mansion of a landowner called Golovinsky.

In 1804–1806, the first theatre in Kyiv was built at one end of the street. It was a wooden structure that was later demolished and replaced by the three-storey European Hotel [uk].

Khreshchatyk began to be developed in the 1830s and 1840s, beginning from the European Square end. Its current design emerged in 1837 when it was planned as Kyiv's principal street by architects that included the city architect, Ludvik Stanzani [uk]. From 1868 banks started to be located on Khreshchatyk. The Kyiv Stock Exchange was built in 1869. The thoroughfare became one of the most famous in the Russian Empire. The new City Hall [uk] was built on the street in 1874–1876. Other notable buildings constructed during this period were the Merchants' Hall, the concert hall, the Central Post Office, and the Club for Polish Noblemen. During the 1880s, its wooden-built restaurants and taverns were being replaced by stone-built multi-storey houses and shops. The street, with its departmental stores and hotels, was called "the only real street in Kiev," and, along with the city’s larger churches, became its central modern attraction for visitors.

The Brotherhood of Saints Cyril and Methodius met at the apartment of 19th-century Ukrainian historian Mykola Kostomarov on Khreshchatyk.