Kilfane Church is a medieval church and National Monument in County Kilkenny, Ireland.

Kilfane Church is located, in Kilfane, approximately 3.4 km (2.1 mi) north-northeast of Thomastown, County Kilkenny.

The area is supposed to derive its name from a Saint Phian.

The church was built in the 13th century. The Cantwells were Lords of Kilfane and adjoining areas from shortly after the Norman conquest to the confiscations following the Confederation.

Poet Deirdre Brennan wrote a poem about Kilfane Church in 2001.

Kilfane Church is a long rectangle with sedilia, altar, book rest and piscina. The sedilia are believed to come from an older church and still have some medieval paint. Three original doorways in the north and south walls are headed by ogee stones.

The castellated tower house at the east end may have housed the presbytery/sacristy and provided residents in the upper storeys.

When the new Church of Ireland building was built across the road, the old church found new use as a schoolhouse.