LHASA (Logic and Heuristics Applied to Synthetic Analysis) is a computer program developed in 1971 by the research group of Elias James Corey at the Harvard University Department of Chemistry. The program uses artificial intelligence techniques to discover sequences of reactions which may be used to synthesize a molecule.^[1] This program was one of the first to use a graphical interface to input and display chemical structures.^[2]

1. ^ Corey, E. J.; Wipke, W. Todd; Cramer, Richard D.; Howe, W. Jeffrey (1972-01-01). "Computer-assisted synthetic analysis. Facile man-machine communication of chemical structure by interactive computer graphics". Journal of the American Chemical Society. 94 (2): 421–430. doi:10.1021/ja00757a020. ISSN 0002-7863.
2. ^ Wang, Zhuang; Zhang, Wenhan; Liu, Bo (2021-06-26). "Computational Analysis of Synthetic Planning: Past and Future". Chinese Journal of Chemistry. 39 (11): 3127–3143. doi:10.1002/cjoc.202100273. ISSN 1001-604X.

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