This is a list of Disney Villain characters, often based on fictional antagonist characters who have been featured as part of the Disney character line-up. Some of these villain characters have appeared in sequels, video games, comic books, stage productions, or live-action adaptations of the original films.

Much like with the Disney Princess line with some of Disney's female lead animated characters, Disney's villain characters are also often grouped together as part of a Disney Villains franchise, formed by various antagonists from Walt Disney Pictures productions, with a main focus on characters from animated films, mainly those from Walt Disney Animation Studios productions.

The characters listed here are featured in Disney productions and merchandise as "official" villains within the Disney Villains franchise.

These characters are seen most frequently in Disney Villains related merchandise, live events, attractions, etc. The characters are also known as "The 13 Reflections of Evil".

These characters appear or have appeared in the franchise less frequently.

In August 2018, a strategy game titled Disney Villainous was designed by Prospero Hall, published by Ravensburger and released exclusively to Target stores. The game has players compete as Disney Villains attempting to accomplish their goals from the film, while simultaneously trying to slow down their opponents. As of March 2021, four standalone expansions have released, with each adding three different playable villains.

Villain merchandise was available at the former Villains in Vogue store in Sunset Blvd, at Disney's Hollywood Studios. This first store was so successful that the Disneyland Villain Shop was opened afterwards in 1991. Both of these have since now closed.^{[citation needed]}

USAopoly has released a number of products featuring Disney villains. Among them is a Monopoly-based board game called My Disney Villains Monopoly; a checkers game; and a collector's card game set.