The Liverpool and Manchester Railway (L&MR) was the first inter-city railway in the world. It opened on 15 September 1830 between the Lancashire towns of Liverpool and Manchester in England. It was also the first railway to rely exclusively on locomotives driven by steam power, with no horse-drawn traffic permitted at any time; the first to be entirely double track throughout its length; the first to have a true signalling system; the first to be fully timetabled; and the first to carry mail.

Trains were hauled by company steam locomotives between the two towns, though private wagons and carriages were allowed. Cable haulage of freight trains was down the steeply-graded 1.26-mile (2.03 km) Wapping Tunnel to Liverpool Docks from Edge Hill junction. The railway was primarily built to provide faster transport of raw materials, finished goods, and passengers between the Port of Liverpool and the cotton mills and factories of Manchester and surrounding towns.

Designed and built by George Stephenson, the line was financially successful, and influenced the development of railways across Britain in the 1830s. In 1845, the railway was absorbed by its principal business partner, the Grand Junction Railway (GJR), which in turn amalgamated the following year with the London and Birmingham Railway and the Manchester and Birmingham Railway to form the London and North Western Railway.

During the Industrial Revolution, huge tonnages of raw material were imported through Liverpool and carried to the textile mills near the Pennines where water, and later steam power, enabled the production of the finished cloth, much of which was then transported back to Liverpool for export. The existing means of water transport, the Mersey and Irwell Navigation, the Bridgewater Canal and the Leeds and Liverpool Canal, dated from the 18th century, and were felt to be making excessive profits from the cotton trade and throttling the growth of Manchester and other towns. Goods were transported between Liverpool and the factories around Manchester either by the canals or by poor-quality roads; the turnpike between Liverpool and Manchester was described as "crooked and rough" with an "infamous" surface. Road accidents were frequent, including waggons and coaches overturning, which made goods traffic problematic.

The proposed railway was intended to achieve cheap transport of raw materials, finished goods and passengers between the Port of Liverpool and east Lancashire, in the port's hinterland. There was support for the railway from both Liverpool and London but Manchester was largely indifferent and opposition came from the canal operators and the two local landowners, the Earl of Derby and the Earl of Sefton, over whose land the railway would cross.

The proposed Liverpool and Manchester Railway was to be one of the earliest land-based public transport systems not using animal traction power. Before then, public railways had been horse-drawn, including the Lake Lock Rail Road (1796), Surrey Iron Railway (1801) and the Oystermouth Railway near Swansea (1807).

The original promoters are usually acknowledged to be Joseph Sandars, a rich Liverpool corn merchant, and John Kennedy, owner of the largest spinning mill in Manchester. They were influenced by William James. James was a land surveyor who had made a fortune in property speculation. He advocated a national network of railways, based on what he had seen of the development of colliery lines and locomotive technology in the north of England.

The Liverpool and Manchester Railway Company was founded on 20 May 1824. It was established by Henry Booth, who became its secretary and treasurer, along with merchants from Liverpool and Manchester. Charles Lawrence was the Chairman, Lister Ellis, Robert Gladstone, John Moss and Joseph Sandars were the Deputy Chairmen.