Lucrezia Borgia is a melodramatic opera in a prologue and two acts by Gaetano Donizetti. Felice Romani wrote the Italian libretto after the play Lucrezia Borgia by Victor Hugo, in its turn after the legend of Lucrezia Borgia. Lucrezia Borgia was first performed on 26 December 1833 at La Scala, Milan.

Because of its scandalous subject matter, Lucrezia Borgia was taken up slowly in Italy and presented in many Italian theatres with altered titles and, in some cases, altered character names. It was given in Florence, beginning on 12 November 1838, as Eustorgia da Romano, in Trieste in the autumn of 1838 as Alfonso Duca di Ferrara, in Ferrara on 14 April 1841 as Giovanna I di Napoli, and in Rome on 26 December 1841 as Elisa da Fosco.

The first London production was at Her Majesty's Theatre on 6 June 1839 with Giulia Grisi and Mario. When the opera was staged in Paris (Théâtre des Italiens) in 1840, Victor Hugo obtained an injunction against further productions within the domain of French copyright law. The libretto was then rewritten and retitled La rinnegata, with the Italian characters changed to Turks, and the performances were resumed.

The first English-language production was in London on 30 December 1843. The English tenor Sims Reeves was a noted Gennaro. Lucrezia was first presented in New Orleans on 27 April 1843 and then at New York's American Theatre on 11 May 1843 and later at the Palmo's Opera House in 1847: with Giulia Grisi in 1854; and with Thérèse Tietjens and Brignoli in 1876. It was given at the Academy of Music, Philadelphia, in 1882, and at the Metropolitan Opera House in New York, in 1904, with Enrico Caruso as Gennaro and Arturo Vigna conducting.

A famous performance of Lucrezia Borgia presented by the American Opera Society Ensemble in 1965 at Carnegie Hall with soprano Montserrat Caballé, who was making her American debut, was soon followed by a recording featuring Caballé, Shirley Verrett, Alfredo Kraus, and Ezio Flagello, conducted by Jonel Perlea, who also led the Carnegie Hall performance.

Lucrezia Borgia is often produced as a vehicle for a star soprano, including Montserrat Caballé, Leyla Gencer, Mariella Devia, Beverly Sills, Dame Joan Sutherland, Renée Fleming, Edita Gruberová and Sondra Radvanovsky.

The Palazzo Grimani in Venice

Gennaro and his friends, including Orsini, celebrate on the brightly lit terrace, in front of which lies the Giudecca Canal ("Bella Venezia!"). The friends' conversation turns to Don Alfonso, Duke of Ferrara, to whose house they will be travelling the next day, and to his wife, the infamous Lucrezia Borgia. On hearing Lucrezia's name, Orsini tells of how Gennaro and he, alone in a forest, were warned by a mysterious old man to beware her and the entire Borgia family, and that the two of them would die together ("Nella fatal di Rimini"). Professing his boredom with Orsini's tale Gennaro wanders off and falls asleep nearby. His friends are invited to rejoin the festivities, and he is left behind ("Senti! La danza invitaci").