MED31

MED31
Identifiers
Aliases	MED31, 3110004H13Rik, Soh1, CGI-125, mediator complex subunit 31
External IDs	MGI: 1914529; HomoloGene: 9368; GeneCards: MED31; OMA:MED31 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.1 Start 6,643,311 bp[1] End 6,651,634 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B4 Start 72,102,550 bp[2] End 72,106,418 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell bronchial epithelial cell anterior pituitary sperm testicle islet of Langerhans prefrontal cortex right adrenal gland right adrenal cortex nucleus accumbens Top expressed in endocardial cushion zygote medial ganglionic eminence facial motor nucleus interventricular septum secondary oocyte atrioventricular valve olfactory epithelium morula right lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription coactivator activity transcription coregulator activity protein binding ubiquitin protein ligase activity Cellular component core mediator complex nucleus nucleoplasm ubiquitin ligase complex mediator complex Biological process regulation of transcription by RNA polymerase II limb development transcription initiation from RNA polymerase II promoter regulation of transcription, DNA-templated negative regulation of fibroblast proliferation protein ubiquitination transcription, DNA-templated positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51003 67279 Ensembl ENSG00000108590 ENSMUSG00000020801 UniProt Q9Y3C7 Q9CXU1 RefSeq (mRNA) NM_016060 NM_026068 RefSeq (protein) NP_057144 NP_080344 Location (UCSC) Chr 17: 6.64 – 6.65 Mb Chr 11: 72.1 – 72.11 Mb PubMed search [3] [4]
Wikidata
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Mediator of RNA polymerase II transcription subunit 31 is a protein in humans encoded by the MED31 gene.^[5][6] It represents subunit Med31 of the Mediator complex. The family contains the Saccharomyces cerevisiae SOH1 homologues. SOH1 is responsible for the repression of temperature sensitive growth of the HPR1 mutant^[7] and has been found to be a component of the RNA polymerase II transcription complex. SOH1 not only interacts with factors involved in DNA repair, but transcription as well. Thus, the SOH1 protein may serve to couple these two processes.^[8]

• Gu W, Malik S, Ito M, et al. (1999). "A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation". Mol. Cell. 3 (1): 97–108. doi:10.1016/S1097-2765(00)80178-1. PMID 10024883.
• Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Res. 11 (10): 1758–1765. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
• Brower CS, Sato S, Tomomori-Sato C, et al. (2002). "Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase". Proc. Natl. Acad. Sci. U.S.A. 99 (16): 10353–10358. Bibcode:2002PNAS...9910353B. doi:10.1073/pnas.162424199. PMC 124918. PMID 12149480.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Sato S, Tomomori-Sato C, Banks CA, et al. (2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". J. Biol. Chem. 278 (17): 15123–15127. doi:10.1074/jbc.C300054200. PMID 12584197.
• Sato S, Tomomori-Sato C, Banks CA, et al. (2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". J. Biol. Chem. 278 (50): 49671–49674. doi:10.1074/jbc.C300444200. PMID 14576168.
• Tomomori-Sato C, Sato S, Parmely TJ, et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". J. Biol. Chem. 279 (7): 5846–5851. doi:10.1074/jbc.M312523200. PMID 14638676.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Sato S, Tomomori-Sato C, Parmely TJ, et al. (2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Mol. Cell. 14 (5): 685–691. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
• Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–865. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–968. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070.

This article incorporates text from the public domain Pfam and InterPro: IPR008831

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

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