The Intel-based MacBook Pro is a discontinued line of Macintosh notebook computers sold by Apple from 2006 to 2021. It was the higher-end model of the MacBook family, sitting above the low-end plastic MacBook and the ultra-portable MacBook Air, and was sold with 13-inch to 17-inch screens.

The MacBook Pro line launched in 2006 as an Intel-based replacement for the PowerBook line. The first MacBook Pro used an aluminum chassis similar to the PowerBook G4, but replaced the PowerPC G4 chips with Intel Core processors, added a webcam, and introduced the MagSafe power connector. The unibody model debuted in October 2008, so-called because its case was machined from a single piece of aluminum. It had a thinner, flush display, a redesigned trackpad whose entire surface consisted of a single clickable button, and a redesigned keyboard.

The retina MacBook Pro was released in 2012: it is thinner, made solid-state drive (SSD) standard, added HDMI, and included a high-resolution Retina display. It eliminated Ethernet and FireWire ports and the optical drive. The Touch Bar MacBook Pro - so-called because of its Touch Bar strip with a Touch ID sensor - released in October 2016, adopted USB-C for all data ports and power and included a shallower "butterfly"-mechanism keyboard. A November 2019 revision to the Touch Bar MacBook Pro introduced the Magic Keyboard, which used a scissor-switch mechanism.

The Intel-based MacBook Pros were succeeded by Apple silicon MacBook Pros beginning in 2020 as part of the Mac transition to Apple silicon. On November 10, 2020, Apple discontinued the two-port 13-inch model following the release of a new model based on the Apple M1. The 16-inch and four-port 13-inch models were discontinued on October 18, 2021, following the release of 14-inch and 16-inch models based on the M1 Pro and M1 Max.

The original 15-inch MacBook Pro was announced on January 10, 2006, by Steve Jobs at the Macworld Conference & Expo. The 17-inch model was unveiled on April 24, 2006. The first design was largely a carryover from the PowerBook G4, but uses Intel Core CPUs instead of PowerPC G4 chips. The 15-inch MacBook Pro weighs the same as the 15-inch aluminum PowerBook G4, but is 0.1 inches (0.25 cm) deeper, 0.4 inches (1.0 cm) wider, and 0.1 inches (0.25 cm) thinner. Other changes from the PowerBook include a built-in iSight webcam and the inclusion of MagSafe, a magnetic power connector designed to detach easily when yanked. These features were later brought over to the MacBook. The optical drive was shrunk to fit into the slimmer MacBook Pro; it runs slower than the optical drive in the PowerBook G4 and cannot write to dual-layer DVDs.

Both the original 15- and 17-inch model MacBook Pro computers come with ExpressCard/34 slots, which replace the PC Card slots found in the PowerBook G4. Initial aluminum 15-inch models retains the two USB 2.0 ports and a FireWire 400 port but drops the FireWire 800, until it was restored in a later revision, the 17-inch models have an additional USB 2.0 port, as well as the FireWire 800 port missing from the initial 15-inch models. All models now included 802.11a/b/g. Later models include support for the draft 2.0 specification of 802.11n and Bluetooth 2.1.

Apple refreshed the entire MacBook Pro line on October 24, 2006, to include Intel Core 2 Duo processors which were the first 64-Bit processors in the MacBook Pro. Memory capacity was doubled for each model, up to 2 GB for the high-end 15- and 17-inch models. FireWire 800 was added to the 15-inch models and hard drive capacity was also increased.

The MacBook Pro line received a second update on June 5, 2007, with new Nvidia GeForce 8600M GT graphics processors and faster CPU options. LED backlighting was added to the 15-inch model's screen, and its weight was reduced from 5.6 pounds (2.5 kg) to 5.4 pounds (2.4 kg). Furthermore, the speed of the front-side bus was increased from 667 to 800 MHz. The EFI also was 64-bit for the first time as well.