Mandello Vitta (Mandel in Piedmontese and in Lombard, IPA pronunciation: /maŋˈdɛl/) is a comune (municipality) in the Province of Novara in the Italian region Piedmont, located about 80 kilometres (50 mi) northeast of Turin and about 13 kilometres (8 mi) northwest of Novara.

The comune is located in the western part of the provincial territory that lies between the rivers Sesia and Agogna.

Mandello Vitta borders the following municipalities: Casaleggio Novara, Castellazzo Novarese, Landiona, Sillavengo, and Vicolungo.

Mandello Vitta is 5 km far from the strada provinciale 299 della Valsesia (SP 299) that connects Novara and Alagna Valsesia, in the Province of Vercelli. The comune is easily accessible by the motorway Autostrada A4 Turin-Trieste through the junction "Biandrate-Vicolungo".

Mandello Vitta is also part of some thematic itineraries of the Province of Novara.

The etymology of the name Mandello derives from the founder Rubaconte da Mandello, Podestà of the Comune of Novara during the 13th century, whose family originated from Mandello del Lario.

The name Vitta was added after the Italian Unification to distinguish Mandello Vitta from Mandello del Lario, a town and comune in Lombardy. Vitta was a family who owned fields and industries in the comune during the 19th century.

Before the foundation of the village, a Lombard settlement may had been present, as remains of a burial ground found here suggest.