Manzac-sur-Vern (French pronunciation: [mɑ̃zak syʁ vɛʁn]; Occitan: Manzac de Vern) is a commune in the Dordogne department in Nouvelle-Aquitaine in southwestern France.

There are near the town both prehistoric Gallo-Roman traces. In the Middle Ages, Manzac had a former Priory of the Abbey of Brantôme and on November 27, 1911, the commune of Manzac was renamed Manzac-sur-Vern

Significant landmarks include the Saint-Pierre-ès-links a 15th-century church with façade (shown right) dating from the 19th century and Gothic bell tower.