Andreessen and Ben Horowitz co-found Andreessen Horowitz (a16z), a venture capital firm focused on investing in early-stage technology companies.

a16z quickly gains prominence through strategic investments in companies like Facebook, Twitter, Airbnb, Skype, and many others. Their approach emphasizes providing operational and strategic support to portfolio companies.

a16z expands its investment focus beyond traditional software and internet companies to include areas like cryptocurrency, biotechnology, and other emerging technologies. The firm raises multiple multi-billion dollar funds.

Andreessen Horowitz remains a highly influential venture capital firm, shaping the technology landscape through its investments and thought leadership.