Marion O'Brien Donovan was born in Fort Wayne, Indiana, to Miles and Christine O'Brien. Her father was an inventor, holding a patent for a lathe. This early exposure to invention and problem-solving likely influenced her future endeavors.

Throughout her childhood, Donovan displayed a keen interest in tinkering and improving existing items. She often helped her father with his inventions, gaining practical experience and a deeper understanding of mechanical processes.

Donovan graduated from Rosemont College near Philadelphia, Pennsylvania, with a degree in English literature. While her formal education wasn't in a scientific or technical field, her strong communication skills proved valuable later in her business ventures.

After graduation, Donovan moved to New York City and worked as an assistant merchandise editor at Vogue magazine. This experience exposed her to the world of fashion, marketing, and consumer needs, providing insights into the practical challenges faced by women.