Mary Louise Kelly (born 1971) is an American broadcaster and author. She anchors the daily news show All Things Considered on National Public Radio (NPR), and hosts the network’s national security podcast Sources & Methods. Prior to NPR she reported for CNN and the BBC in London. Her writing has appeared in The New York Times, The Washington Post, The Wall Street Journal, Newsweek, The Atlantic, and other publications. Her first novel, Anonymous Sources, was published in 2013; her second, The Bullet, in 2015; and her memoir, It. Goes. So. Fast.: The Year of No Do-Overs, in 2023.

Mary Louise Kelly was born in Augsburg, West Germany, the daughter of Carol (White) and James Patrick Kelly. While her father was attending Harvard University, he was drafted out of law school into the United States Army. He and Carol moved to Augsburg, Germany, where Mary Louise was born in an Army field hospital. James served as a captain from 1968 to 1972.

Mary Louise Kelly grew up in Atlanta, Georgia. She graduated magna cum laude from Harvard University in 1993, studying government, French language, and literature. As a senior editor at The Harvard Crimson, she covered the 1992 presidential election and the first inauguration of President Bill Clinton.

In 1993, she landed her first job in reporting at The Atlanta Journal-Constitution, where she stayed for a year before leaving for the U.K. to pursue a second degree. In 1995, she graduated with a master's in European studies from Emmanuel College, Cambridge. During that same academic year she interned with the BBC in Glasgow and London.

Kelly's first post-college job was reporting on local politics for her hometown newspaper, The Atlanta Journal-Constitution. After her post-graduate studies in Cambridge, England, and internships at the British Broadcasting Corporation (BBC) in Scotland and London, Kelly joined the Boston team that launched the radio news magazine The World, a joint venture between the BBC and Public Radio International.

The following year, Kelly returned to the United Kingdom, working as a host, foreign correspondent and senior producer for the BBC World Service, and as a producer at CNN in London. Kelly reported from the Afghan-Pakistan border, radical Hamburg mosques, Kosovo refugee camps, and the deck of an aircraft carrier. At the BBC, she covered the peace talks that ended The Troubles in Northern Ireland.

Kelly returned to the United States in 2001 to join National Public Radio in Washington, D.C. For three years, she edited NPR's evening news magazine, All Things Considered. The NPR website described her as a "bad-ass babe on breaking news".

In 2004, Kelly launched NPR's intelligence beat, reporting on spy agencies like the Central Intelligence Agency (CIA), the Defense Intelligence Agency, and the National Security Agency. In 2005, Kelly became the first reporter to interview Gary Schroen, the CIA operative who was dropped into Afghanistan in the aftermath of the September 11 attacks with a six-man team and a directive to bring back the head of Osama bin Laden. In 2006, Kelly broke the news of the CIA's secret decision to disband the unit aimed at searching for bin Laden. The story caused an uproar and led to the U.S. Senate voting on September 8, 2006, to reinstate the unit.