The Axiom of Maria is a fundamental alchemical principle often attributed to Mary the Jewess. It stated, "One becomes two, two becomes three, and out of the third comes the one as the fourth." This cryptic saying encapsulates the alchemical process of transformation and the cyclical nature of matter, emphasizing the interconnectedness of all things. It reflects a holistic view of the alchemical process.

Mary's alchemical practice emphasized the importance of separating substances into their constituent parts and then recombining them in new ways to achieve transmutation. This concept is a cornerstone of alchemical laboratory work and highlights the importance of precise control and understanding of materials. This laid the groundwork for experimental methodology.

While primarily known through fragments, Mary's legacy implies a focus on practical application and experimentation in alchemy. The invention of the Tribikos and Kerotakis showcases a dedication to developing tools that facilitate alchemical processes, underscoring her emphasis on hands-on manipulation of matter. This distinguishes her as a pragmatic alchemist.