Matthew Abram Groening (/ˈɡreɪnɪŋ/ GRAY-ning; born February 15, 1954) is an American cartoonist, writer, producer, and animator. He is the creator of the television series The Simpsons (1989–present), Futurama (1999–2003, 2008–2013, 2023–present), and Disenchantment (2018–2023), and the comic strip Life in Hell (1977–2012).

Born in Portland, Oregon, Groening made his first professional cartoon sale of Life in Hell to the avant-garde magazine Wet in 1978. At its peak, it was carried in 250 weekly newspapers and caught the attention of the producer James L. Brooks, who contacted Groening in 1985 about adapting it for animated sequences for the Fox variety show The Tracey Ullman Show. Fearing the loss of ownership rights, Groening created a new set of characters, the Simpson family. The shorts were spun off into their own series, The Simpsons, which became the longest-running American primetime television series and the longest-running American animated series and sitcom.

In 1997, Groening and former Simpsons writer David X. Cohen developed Futurama, an animated series about life in the year 3000, which premiered in 1999. It ran for four years on Fox, was picked up in 2008 by Comedy Central for another 5 years, and was picked up again by Hulu in 2023. In 2016, Groening developed a series for Netflix, Disenchantment, which premiered in August 2018.

Groening has won 14 Primetime Emmy Awards, 12 for The Simpsons and 2 for Futurama, and a British Comedy Award for "outstanding contribution to comedy" in 2004. In 2002, he won the National Cartoonist Society Reuben Award for his work on Life in Hell. He received a star on the Hollywood Walk of Fame on February 14, 2012.

Matthew Abram Groening was born on February 15, 1954, in Portland, Oregon, the middle of five children (older sister Patty and brother Mark were born in 1943 and 1950, and younger sisters Lisa and Maggie in 1956 and 1958, respectively). His Norwegian American mother, Margaret Ruth (née Wiggum; March 23, 1919 – April 22, 2013), was once a teacher, and his Canadian Mennonite father, Homer Philip Groening (December 30, 1919 – March 15, 1996), was a filmmaker, advertiser, writer and cartoonist. Homer, born in Main Centre, Saskatchewan, Canada, grew up in a Plautdietsch-speaking family.

Groening's grandfather, Abram A. Groening, was a professor at Tabor College, a Mennonite Brethren liberal arts college in Hillsboro, Kansas, before moving to Albany College (now known as Lewis and Clark College) in Oregon in 1930.

Groening was raised in Portland and attended Ainsworth Elementary School and Lincoln High School. Following his high school graduation in 1972, Groening attended The Evergreen State College in Olympia, Washington, a liberal arts school that he described as "a hippie college, with no grades or required classes, that drew every weirdo in the Northwest." He served as the editor of the campus newspaper, The Cooper Point Journal, for which he also wrote articles and drew cartoons. Groening graduated with a Bachelor of Arts in journalism in 1977. He befriended fellow cartoonist Lynda Barry after discovering that she had written a fan letter to Joseph Heller, one of Groening's favorite authors, and had received a reply. Groening has credited Barry with being "probably [his] biggest inspiration." He first became interested in cartoons after watching the Disney animated film One Hundred and One Dalmatians as well as Monty Python.

In 1977, at age 23, Groening moved to Los Angeles to become a writer. He went through several jobs, including being an extra in the television film When Every Day Was the Fourth of July, busing tables, washing dishes at a nursing home, clerking at the Hollywood Licorice Pizza record store, landscaping in a sewage treatment plant, and chauffeuring and ghostwriting for a retired director of Western films.