Albania in the Middle Ages was a period during the European Middle Ages when the Roman Empire divided into east and west in 395, the territories of modern Albania became a part of the Byzantine Empire. At the end of the 12th century, the Principality of Arbanon was formed which lasted until mid-13th century, after its dissolution it was followed with the creation of the Albanian Kingdom after an alliance between the Albanian noblemen and Angevin dynasty. After a war against the Byzantine Empire led the kingdom occasionally decrease in size until the Angevins eventually lost their rule in Albania and led the territory ruled by several different Albanian chieftains until the mid-14th century which for a short period of time were conquered by the short-lived empire of Serbia. After its fall in 1355 several chieftains regained their rule and significantly expanded until the arrival of the Ottomans after the Battle of Savra.

After the Battle of Savra in 1385 most of local chieftains became Ottoman vassals. In 1415–1417 most of the central and southern Albania was incorporated into the Ottoman Empire and its newly established Sanjak of Albania. In 1432-36 local Albanian chieftains dissatisfied with losing their pre-Ottoman privileges organized a revolt in southern Albania. The revolt was suppressed until another revolt was organized by Skanderbeg in 1443, after the Ottoman defeat in the Battle of Niš, during the Crusade of Varna. In 1444, Gjergj Kastrioti Skanderbeg was proclaimed as the leader of the regional Albanian chieftains and nobles united against the Ottoman Empire in the League of Lezhë disestablished in 1479. Skanderbeg's rebellion against the Ottoman Empire lasted for 25 years. Despite his military valor he was not able to do more than to hold his own possessions within the very small area in the North Albania where almost all his victories against the Ottomans took place. By 1479 the Ottomans captured all Venetian possessions, except Durazzo which they captured in 1501. Until 1913 the territory of Albania would remain part of the Ottoman Empire.

The Komani-Kruja culture is an archaeological culture attested from late antiquity to the Middle Ages in central and northern Albania, southern Montenegro and similar sites in the western parts of North Macedonia. It consists of settlements usually built below hillforts along the Lezhë (Praevalitana)-Dardania and Via Egnatia road networks which connected the Adriatic coastline with the central Balkan Roman provinces. Its type site is Komani and its fort on the nearby Dalmace hill in the Drin river valley. Kruja and Lezha represent significant sites of the culture. The population of Komani-Kruja represents a local, western Balkan people which was linked to the Roman Justinianic military system of forts. The development of Komani-Kruja is significant for the study of the transition between the classical antiquity population of Albania to the medieval Albanians who were attested in historical records in the 11th century.

Research greatly expanded after 2009 and the first survey of Komani's topography was produced in 2014. Until then, except for the area of the cemetery the size of the settlement and its extension remained unknown. In 2014, it was revealed that Komani occupied an area of more than 40 ha, a much larger territory than originally thought. Its oldest settlement phase dates to the Hellenistic era. Proper development began in the late antiquity and continued well into the Middle Ages (13th-14th centuries). It indicates that Komani was a late Roman fort and an important trading node in the networks of Praevalitana and Dardania. Participation in trade networks of the eastern Mediterranean via sea routes seems to have been very limited even in nearby coastal territory in this era. In the Avar-Slavic raids, communities from present-day northern Albania and nearby areas clustered around hill sites for better protection as is the case of other areas like Lezha and Sarda. During the 7th century as Byzantine authority was reestablished after the Avar-Slavic raids and the prosperity of the settlements increased, Komani saw increase in population and a new elite began to take shape. Increase in population and wealth was marked by the establishment of new settlements and new churches in their vicinity. Komani formed a local network with Lezha and Kruja and in turn this network was integrated in the wider Byzantine Mediterranean world, maintained contacts with the northern Balkans and engaged in long-distance trade.

Arbanon was an autonomous principality that existed between the late 12th century and the 1250s. Throughout its existence, the principality was an autonomous dependency of its neighbouring powers, first Byzantium and, after the Fourth Crusade, Epirus, while it also maintained close relations with Serbia. Arbanon extended over the modern districts of central Albania, with the capital at Kruja, and it did not have direct access to the sea. Progon was the first ruler, believed to have ruled in ca. 1190. He was succeeded by his sons Gjin (r. c. 1200–08) and Dimitri (r. 1208–16). After this dynasty, the principality came under Greek lord Gregory Kamonas and then his son-in-law Golem. Dimitri's widow, Serbian princess Komnena Nemanjić, had inherited the rule and remarried Kamonas. Arbanon declined after a rebellion against Nicaea in favour of Epirus in 1257–58.

After the fall of the Principality of Arber in its territories and in territories captured by the Despotate of Epiros was created the Kingdom of Albania, which was established by Charles of Anjou. He took the title of King of Albania in February, 1272. The kingdom extended from Durazzo (modern Durrës) south along the coast to Cape Linguetta, with vaguely defined borders in the interior. A Byzantine counter-offensive soon ensued, which drove the Angevins out of the interior by 1281. The Sicilian Vespers further weakened the position of Charles, and the Kingdom was soon reduced by the Epirotes to a small area around Durrës. The Angevins held out here, however, until 1368, when the city was captured by Karl Thopia.

After the fall of the Principality of Arber in territories captured by the Despotate of Epirus, the Kingdom of Albania was established by Charles of Anjou. He took the title of King of Albania in February 1272. The kingdom extended from the region of Durrës (then known as Dyrrhachium) south along the coast to Butrint. After the failure of the Eighth Crusade, Charles of Anjou returned his attention to Albania. He began contacting local Albanian leaders through local catholic clergy. Two local Catholic priests, namely John from Durrës and Nicola from Arbanon, acted as negotiators between Charles of Anjou and the local noblemen. During 1271 they made several trips between Albania and Italy eventually succeeding in their mission.

On 21 February 1272, a delegation of Albanian noblemen and citizens from Durrës made their way to Charles' court. Charles signed a treaty with them and was proclaimed King of Albania "by common consent of the bishops, counts, barons, soldiers and citizens" promising to protect them and to honor the privileges they had from Byzantine Empire. The treaty declared the union between the Kingdom of Albania (Latin: Regnum Albanie) with the Kingdom of Sicily under King Charles of Anjou (Carolus I, dei gratia rex Siciliae et Albaniae). He appointed Gazzo Chinardo as his Vicar-General and hoped to take up his expedition against Constantinople again. Throughout 1272 and 1273 he sent huge provisions to the towns of Durrës and Vlorë. This alarmed the Byzantine Emperor, Michael VIII Palaiologos, who began sending letters to local Albanian nobles, trying to convince them to stop their support for Charles of Anjou and to switch sides. However, the Albanian nobles placed their trust on Charles, who praised them for their loyalty. But Charles of Anjou imposed a military rule on Kingdom of Albania.