Mesoamerican pyramids form a prominent part of ancient Mesoamerican architecture. Although similar in some ways to Egyptian pyramids, these New World structures have flat tops (many with temples on the top) and stairs ascending their faces, more similar to ancient Mesopotamian Ziggurats. Most pyramids had square bases, but there were also pyramids of other shapes, including rounded ones. The largest pyramid in the world by volume is the Great Pyramid of Cholula, in the east-central Mexican state of Puebla. The builders of certain classic Mesoamerican pyramids have decorated them copiously with stories about the Hero Twins, the feathered serpent Quetzalcoatl, Mesoamerican creation myths, ritualistic sacrifice, etc. written in the form of Maya script on the rises of the steps of the pyramids, on the walls, and on the sculptures contained within.

The Aztecs dominated central Mexico in the 14th, 15th and 16th centuries. Their capital was Tenochtitlan on the shore of Lake Texcoco – the site of modern-day Mexico City. They were related to the preceding cultures in the basin of Mexico such as the culture of Teotihuacan whose building style they adopted and adapted. Sites involving Aztec pyramids include:

The Maya are a people of southern Mexico and northern Central America (Guatemala, Belize, western Honduras, and El Salvador). Archaeological evidence shows that by the Preclassic Maya (1000 B.C., approximately 3,000 years ago) they were building pyramidal-plaza ceremonial architecture. The earliest monuments consisted of simple burial mounds, the precursors to the spectacular stepped pyramids from the Terminal Pre-classic period and beyond.

Mayan temples have a pyramid-like structure. These pyramids relied on intricate carved stone in order to create a stair-stepped design. Many of these structures featured a top platform upon which a smaller dedicatory building was constructed, associated with a particular Maya deity. Maya pyramid-like structures were also erected to serve as a place of interment for powerful rulers. Maya pyramidal structures occur in a great variety of forms and functions, bounded by regional and periodical differences.

The Olmecs were an ancient group of indigenous peoples that occupied territory in Mesoamerica stretching from Veracruz to Tabasco around 1300-400 BCE.

The Olmec Great Pyramid of La Venta is argued to be one of the earliest and most complex settlement and ceremonial sites that can be found amongst Mesoamerican civilizations.

The Tarascan state was a pre-columbian culture located in the modern day Mexican state of Michoacán. The region is currently inhabited by the modern descendants of the Purépecha. Purépechan architecture is noted for T-shaped step pyramids known as yácatas.

The Teotihuacan civilization, which flourished from around 300 BCE to 500 CE, at its greatest extent included most of Mesoamerica. Teotihuacano culture collapsed around 550 and was followed by several large city-states such as Xochicalco (whose inhabitants were probably of Matlatzinca ethnicity), Cholula (whose inhabitants were probably Oto-Manguean), and later the ceremonial site of Tula (which has traditionally been claimed to have been built by Toltecs but which now is thought to have been founded by the Huastec culture).