Mestizo Colombians (Spanish: Colombianos mestizos) are Colombians of varying degrees of mixed European (mostly Spanish), Indigenous, and African ancestry.

The 2018 census reported that 87% of the population did not consider themselves part of a listed ethnic group, instead being mostly Mestizo and White.

External sources found Mestizos are the main racial group in Colombia, making up between 49% and 60% of country's population. Chibcha mestizos make up around 10 million people or 20% of Colombia's population. According to Latinobarometro in 2023, 50% of Colombians surveyed self-identified as Mestizos.

According to a genetic study published in PLOS Genetics, people who autoidentified as "Mestizo" in Colombia show an ancestry profile characterized by approximately 62% European, 28% Indigenous American, 6% African, and 4% Arab ancestry.

A 2023 genetic study conducted by Criollo et al. estimated that the average admixture for Mestizo Colombians is 50.8% European, 40.7% Indigenous, and 8.5% African ancestry, however this varies significantly across regions of the country.