Mezzani (Parmigiano: Amzan or Mzan, IPA: [(a)mˈzaŋ]) is a comune (municipality) in the Province of Parma in the Italian region Emilia-Romagna, located about 90 kilometres (56 mi) northwest of Bologna and about 15 kilometres (9 mi) northeast of Parma. The principal centres of the municipality are Casale, Mezzano Rondani, Mezzano Inferiore, Mezzano Superiore, whereas Bocca d’Enza, Ghiare Bonvisi, Valle are only hamlets. Mezzani borders the following municipalities: Brescello, Casalmaggiore, Colorno, Parma, Sorbolo, Torrile, Viadana.

Mezzani lies on the northeastern end of the province of Parma, in the middle of Po Valley and borders with three provinces: Reggio Emilia, Mantua, Cremona.

Located on the right shore of the Po River, the municipal territory is crossed by others watercourses too: the torrent Parma on the west, that flows into Po near Mezzano Superiore, the torrent Enza that follows for some kilometres the eastern border with the Reggio Emilia, the Parmetta canal southwards of Mezzano Inferiore and the Parma morta abandoned riverbed of Parma torrent that up to the first years of 19th century flowed into Enza.

Mezzani is located in the lowest area of Po Valley called Bassa.

The toponym Mezzani comes from Latin word medianus, meaning "in the middle of", once used to name islands on river Po. This territory originated largely from these islands in medieval times and it was continuously reshaped from river waters. Therefore signs of ancient settlements were not found here, but not far from municipality’s boundaries in Cogozzo not far from Viadana and near Coenzo were found traces of two Bronze Age villages called terramare. The southern part of the territory still shows the signs of Roman centuriation.

Casale, the oldest inhabited centre, was founded on a river island; in 890 it was defined as "insula iuxta Padum" (island near Po) to become some century later "Casalis Ripae Padi" (that means Casale near Po riverside) because the river moved northwards. The ancient river presence is testified from the toponym Valle (hollow) located southwards.

Since their formation as islands of Po river, Mezzano Inferiore and Superiore where possession of Parma's Bishop. Some ancient documents talk about alluvial lands near river Po owned from the Bishop after concession of Holy Roman Emperors Charles III the Fat in 973 and Henry VI in 1195. Abbot Giovanni Romani mentioned an event which happened near the "Mezzano del Vescovo" in 1131. The above-mentioned centres originated in different periods: the first one was Mezzano Superiore, the other certainly after 1306. Mezzano Inferiore become autonomous from Mezzano Superiore in the early 16th century with the construction of a parochial church, rebuilt in 1563 and finished in 1779.

Mezzano Rondani was founded on the Lombard bank of Po. After a big flood that interested the area from Casalmaggiore to Fossacaprara and moved northwards the river course, the place became an island and then was joined to Parmesan bank. The word Rondani comes from the surname of a rich family owner of many possessions in that area.