Miss Universe Ghana, whose slogan is Ghana's Next Sweetheart, is a national pageant that sends representatives to the Miss Universe pageant. This pageant is unrelated to Miss Ghana or Miss Earth Ghana pageant. The current Miss Universe Ghana is Andromeda Peters.

The Miss Universe Ghana launched for the first time in 1999. The pageant independently built to select the Ghanaian representative at Miss Universe pageant. R. Ayote Okyne took over the license from Miss Ghana pageant who operated for long in the country. The Miss Universe Ghana Organization in May 2017 handed to former Miss Universe Ghana winner, Menaye Donkor under Malz Productions, until the owner finally gave up the license in 2022 period.

The Miss Universe Ghana competition is traditionally holding region representation every year. The 16 region representatives will compete for the crown. In the finale result there will be Second Runner-up, First Runner-up, then finally Miss Universe Ghana winner.