Mohammad Shaker Kargar (Dari: محمد شاکر کارگر, born 2 February 1967) is an Afghan politician, who has served as the chief of staff to President Ashraf Ghani of the Islamic Republic of Afghanistan.

Shaker Kargar was born on 2 February 1967 in Andkhoy District, Faryab province (Afghanistan). His father - Abdul Rasul Kargar - is a famous teacher and a mayor of the city Andkhoy.

Mohammad Shaker started his primary education in 1973 at Andkhoy central school, and then continued his secondary education at Shah Shahid School in Kabul province and finally ended a high school at Abu Muslim Andkhoy with honour.

For the higher education, he enrolled at the Kabul University in 1984. Then he received a scholarship for continued study at master level in the field of Rights and History at Governmental University of Hertsen Petersburg in 1991. Finally, M. Shaker received a doctorate in philosophical sciences.

In 2011 Mohammad Shaker Kargar has received an Honorary doctorate in international law from The Herzen State Pedagogical University of Russia.

Educated in 1993, Mohammad Shaker has started working as CEO of international business companies. For peace and stability in Afghanistan, he also participates in many national and international peaceful and political meetings in different countries, such as the United States, Canada, the Netherlands, Turkey, Italy and The Commonwealth of Independent States.

In 2001 he participated in the Bonn conference as the First Deputy President of Afghanistan and representative of Abdul Rashid Dostum, after that he was commissioned to head The Ministry of Energy and Water Resources as part of the interim government of the Islamic Republic of Afghanistan.

In 2002 following the results of the Bonn conference, Shaker became one of the 5 vice presidents of Afghan Transitional Authority.