Moorefield is a town in and the county seat of Hardy County, West Virginia, United States. It is located at the confluence of the South Branch Potomac River and the South Fork South Branch Potomac River. Moorefield was originally chartered in 1777; it was named for Conrad Moore, who owned the land upon which the town was laid out. The population was 2,527 at the 2020 census.

Moorefield is situated in the South Branch Valley along the South Branch of the Potomac River. Native Americans populated this area for thousands of years. For centuries, they farmed along the river and hunted in the surrounding mountains. The historic Shawnee people, who spoke a Central Algonquian language in the same family as other tribes in their region, occupied this area when Anglo-European settlers began arriving in the early 18th century, attracted by the fertile land. This early settlement was centered on the community of Old Fields, referring to former Native American lands. This is located about five miles to the north of present-day Moorefield.

Conflict between the mostly British settlers and Native American peoples broke out during the French and Indian War. The British colonists constructed two fortifications to guard the South Branch Valley in the vicinity of Moorefield. Fort Buttermilk was erected in 1756 and garrisoned by Captain Thomas Waggoner's Virginia Regiment Company. A second fortress, Fort Pleasant, situated at Henry Van Meter's Farm at Old Fields, guarded the northern side of the valley. It was also garrisoned by Waggoner's Virginia Regiment Company. In the spring of 1756, soldiers from Forts Buttermilk and Pleasant clashed with Shawnee warriors under Bemino (also known as Killbuck) at the Battle of the Trough.

Colonist Conrad Moore owned the land on which Moorefield was laid out. In 1777, the Virginia General Assembly chartered the town of Moorefield in what was then Hampshire County, Virginia (today Hardy County, West Virginia). When Hardy County was separated from Hampshire County by act of the Virginia General Assembly in 1785, after the American Revolution, Moorefield was chosen as the county seat. Many of the historic houses in Moorefield date to the last quarter of the 18th century and first quarter of the 19th century; they display vernacular adaptations of Federal and Greek Revival architecture.

During the American Civil War, Moorefield was the site of a cavalry engagement between Union Brigadier General William W. Averell and Confederate Brigadier General John McCausland on August 7, 1864, in which Averell routed McCausland. This was part of the Valley Campaigns of 1864. That summer, Averell was the only Union commander to achieve successes against Confederate forces.

The main highways serving Moorefield include U.S. Route 48, which traverses the region from west to east, and U.S. Route 220, which crosses from south to north through the area. West Virginia Route 55 and West Virginia Route 28 also serve Moorefield, but both mostly run concurrently with the aforementioned U.S. highways.

The Potomac Valley Transit Authority operates bus service to Moorefield and surrounding counties. Fixed routes 101, 102, and 103 and on-demand route 303 service the town.

Moorefield is located at 39°4′N 78°58′W / 39.067°N 78.967°W / 39.067; -78.967 (39.063, -78.966).