Mulberry Street is a principal thoroughfare in Lower Manhattan, New York City, United States. It is historically associated with Italian-American culture and history, and in the late 19th and early 20th centuries was the heart of Manhattan's Little Italy.

The street was listed on maps of the area since at least 1755. The "Bend" in Mulberry, where the street changes direction from southeast to northwest to a northerly direction, was made to avoid the wetlands surrounding the Collect Pond. During the period of the American Revolution, Mulberry Street was usually referred to as "Slaughter-house Street", named for the slaughterhouse of Nicholas Bayard on what is now the southwest corner of Mulberry and Bayard Streets, which was located there until the summer of 1784, when it was ordered to be removed to Corlaer's Hook.

Mulberry Bend, formed by Mulberry Street on the east and Orange Street on the west, was historically part of the core of the infamous Five Points; the southwest corner of Mulberry Bend formed part of the Five Points intersection for which the neighborhood was named. Aside from Mulberry, the other four streets forming Five Points were Anthony Street (now Worth Street), Cross Street (now Mosco Street), Orange Street (now Baxter Street), and Little Water Street (which no longer exists).

Mulberry is located between Baxter and Mott Streets. It runs north to south, through the centers of Little Australia and Little Italy, parallel to Mott Street one block to the east, is bound on the north by Bleecker Street in NoHo and on the south by Worth Street in the Civic Center. Near the southern portion of Mulberry Street, the street enters Chinatown, where it is lined with Chinese green grocers, butcher stores, and fishmongers.

Further south past Bayard Street, on the west side of the street, lies Columbus Park, which was created in 1897. The southwest corner of the park (away from Mulberry Street) is the site of the original Five Points intersection. The east side of the street is now lined with Chinatown's funeral homes.^{[citation needed]}

The street was named after the mulberry trees that once lined Mulberry Bend, the slight bend in Mulberry Street. "Mulberry Bend is a narrow bend in Mulberry Street, a tortuous ravine of tall tenement-houses ... so full of people that the throngs going and coming spread off the sidewalk nearly to the middle of the street ... The crowds are in the street because much of the sidewalk and all of the gutter is taken up with vendors' stands."

For the urban reformer Jacob Riis, Mulberry Bend epitomized the worst of the city's slums: "A Mulberry Bend Alley" contrasted with "Mulberry Bend becomes a park" were two of the photographs illustrating Jacob Riis's call for renewal in The Battle with the Slum (1902). In response to reformers such as Riis, the city in the 1890s bought out many of the slumlords and replaced tenements with Columbus Park.

The Puck Building stands near the north end of the street on the southwest corner of Houston Street. Further south is Saint Patrick's Old Cathedral, standing in its churchyard. The Church of the Most Precious Blood, at 113 Baxter Street, was built by Italians, who as new immigrants were not allowed to worship in the main Churches of Transfiguration nor St. Patrick's Old Cathedral. Below Prince Street (no. 247) is the former Ravenite Social Club, where wire taps acquired evidence that sent John Gotti to prison.^{[citation needed]}