Natasha Lyonne was born in New York City to Ivette Buchinger and Aaron Braunstein, a boxing promoter, race car driver, and radio host.

Lyonne began her acting career as a child, appearing in films and television shows such as 'Pee-wee's Playhouse' and 'Heartburn'.

Lyonne attended the Tisch School of the Arts, furthering her education in acting and the arts.