Lyonne played the role of Nicky Nichols in the Netflix series 'Orange Is the New Black', earning critical acclaim and multiple award nominations.

Lyonne co-created, wrote for, directed, and starred in the Netflix series 'Russian Doll', a project that showcased her multifaceted talents.

Lyonne stars in the Peacock series 'Poker Face', a role that continues to highlight her acting prowess.