The National Institute for Interdisciplinary Science and Technology (NIIST, formerly Regional Research Laboratory, Trivandrum) is a constituent laboratory of CSIR, India, engaged in research and development activities in the field of agroprocessing and technology, microbial processes and technology, chemical sciences and technology, material sciences and technology and process engineering and environmental technology. Around approximately 80 scientists and 300 research fellows are working in various scientific disciplines in this institute. The programmes have a blend of basic research, technology development and commercialization; have specific thrusts on frontier areas of research, National Mission Projects, regional resource-based activities and R & D - Industry - Academia linkages. The laboratory has collaborative programmes with major National & International agencies too. the present director of the institute is Dr.C. Anandharamakrishnan.

It was established in 1975 as a CSIR Complex, then named as the Regional Research Laboratory in 1978 and later renamed as NIIST in 2007.

The major research divisions in NIIST are:

1. Agroprocessing and technology division (APTD)
2. Centre for Sustainable Energy Technologies (C-SET)
3. Chemical sciences and technology division (CSTD)

4. Environmental technology division (ETD)
5. Materials science and technology division (MSTD)
6. Microbial processes and technology division (MPTD)
7. Artificial intelligence and Machine Learning (AI&ML) Unit

Materials Science and Technology division has divided into Functional Materials and Minerals and Metallic Materials sections.

Functional Materials has activities related to nano-ceramics, energy materials, polymeric materials, electronic materials and magnetic materials.

Minerals and Metallic Materials has activities related to metals and minerals.