Ndabaningi Sithole (21 July 1920 – 12 December 2000) was a Zimbabwean politician and statesman who, in July 1963, founded the Zimbabwe African National Union (ZANU), a militant, nationalist organisation that opposed the government of Rhodesia. He worked as a United Church of Christ in Zimbabwe (UCCZ) minister. He spent 10 years in prison after the government banned ZANU. A rift along tribal lines split ZANU in 1975, and he lost the 1980 elections to Robert Mugabe.

Sithole was born in Nyamandlovu, Southern Rhodesia, on 21 July 1920. Sithole's father was Ndau and his mother was Ndebele. He studied education in the United States from 1955 to 1958, and was ordained a Methodist minister in 1958. The publication of his book African Nationalism and its immediate prohibition by the minority government motivated his entry into politics. During his studies in the United States, he attended the Andover Newton Theological School and the First Church in Newton (which was founded in 1665), both of which are located in Newton, Massachusetts.

Sithole was one of the founders and chief architect of the Zimbabwe African National Union party in August 1963, in conjunction with Herbert Chitepo, Robert Mugabe and Edgar Tekere in the Highfields House of Enos Nkala. In 1964, there was a party Congress at Gwelo, where Sithole was elected president and Robert Mugabe was appointed to be his secretary general. ZANU was banned in 1964 by Ian Smith's government. After being arrested on 22 June 1964, Sithole spent 10 years in prison. alongside Mugabe, Tekere, Nyagumbo and Takawira for his political activities. While in prison, he specifically authorised Chitepo to continue the struggle from abroad as a representative of ZANU. Sithole was convicted on a charge of plotting to assassinate Ian Smith, and he was released from prison in 1974.

On 18 March 1975, Chitepo was assassinated in Lusaka, Zambia, with a car bomb. Mugabe, in Mozambique at the time, was unanimously chosen to be the first secretary of ZANU. There was a factional split later that year, with many Ndebele following Joshua Nkomo into the equally militant ZAPU. Sithole eventually founded the moderate ZANU-Ndonga party, which renounced violent struggle, while the Shona-dominated ZANU (now called ZANU PF) followed Mugabe with a more militant agenda.

Sithole joined Abel Muzorewa's transitional government under the Internal Settlement on 31 July 1979. In September 1979, he attended the Lancaster House Agreement, chaired by Lord Carrington, which paved the way for fresh elections, but his ZANU-Ndonga Party's supporters and their villages were targeted by Mugabe's ZANLA troops and it failed to win any seats in the 1980 elections.

Sithole's exit from ZANU was claimed by Mugabe to have been caused by his neglecting the fighters in Zambia (where their camp was bombed, resulting in many fatalities and casualties).

Declaring that his life was in danger from political enemies, Sithole went into self-imposed exile, first in the United Kingdom in the early-1980s and then in Silver Spring, Maryland, United States, around 1984, not returning to Zimbabwe until January 1992.

He was elected to parliament for his tribal stronghold of Chipinge in southeastern Zimbabwe in 1995, and was a candidate in the 1996 presidential election (though he withdrew shortly before the election after claiming that Mugabe's ZANU-PF was undermining his campaign). In December 1997, a court tried and convicted him of conspiring with Chimwenje to assassinate Mugabe, and the government disqualified him from attending parliament. Sithole's small opposition group again won the Chipinge seat in the June 2000 elections.