Nicole Eisenman (born 1965) is a French-born American artist known for her oil paintings and sculptures. She has been awarded the Guggenheim Fellowship (1996), the Carnegie Prize (2013), and has thrice been included in the Whitney Biennial (1995, 2012, 2019). On September 29, 2015, she won a MacArthur Fellowship award for "restoring the representation of the human form a cultural significance that had waned during the ascendancy of abstraction in the 20th century."

Eisenman lives in Brooklyn.

Nicole Eisenman was born in 1965 in Verdun, France where her father was stationed as an army psychiatrist. She is of German-Jewish descent; her great-grandmother was Esther Hamerman, a Polish-born painter.

In 1970, Eisenman's family moved from France to Scarsdale, New York, where she spent her childhood. She attended the Rhode Island School of Design, graduating with a B.F.A in painting in 1987. She then moved to New York City.

Between 2003 and 2009, Eisenman taught at Bard College in Annandale-on-Hudson.

Eisenman's figurative oil paintings often toy with themes of sexuality, comedy, and caricature. Though she is known for her paintings, the artist also creates installations, drawings, etchings, lithography, monotypes, woodcuts, and sculptures. With A.L. Steiner, she is the co-founder of the queer/feminist curatorial initiative Ridykeulous. Eisenman's work was included in the 2022 exhibition Women Painting Women at the Modern Art Museum of Fort Worth.

Eisenman also created sculptures that have been shown at the 58th Venice Biennale, 2017 Skulptur Projekte Münster, and the 2019 Whitney Biennial. Eisenman began working on Sketch for a Fountain in 2012, a bronze piece acquired by the Nasher Sculpture Center in 2019. The acquisition was funded by the Kaleta A. Doolin Acquisitions Fund for Women Artists and the Green Family Collection.

Eisenman has created large scale painted murals for venues including the Drawing Center, Trial Ballroom New York, ICA London, and the Whitney Museum.