Kwame Nsiah-Apau (born 17 April 1976), known by his stage name Okyeame Kwame and nicknamed Rap Doctor, is a Ghanaian musician, songwriter, creative director fashion icon and a Developmental Activist. His dual roles as an artist and an activist have led to his recognition as an "artivist."

Apau was born in Kumasi, Ashanti Region of Ghana. He is the third of six siblings. His two younger brothers, Kwaku Nsiah Boamah nicknamed "Flowking Stone" and Kwaku Nsiah Amankwah nicknamed "Kunta Kinte", also perform as a duo, under the brand name "Bradez". Growing up, Kwame's parents expected him to become a physician, yet he gained interest in rap music from a very young age, when he wrote his own songs and performed at local shows since his days at the Anglican Senior High School in Kumasi. His Primary education was difficult because he suffered from dyslexia, which posed challenges for him in learning, particularly in the areas of reading and writing. Based on his childhood experiences, he has been actively promoting the inclusion of dyslexia management in the school curriculum in Ghana.

Kwame is a product of Kwame Nkrumah University of Science and Technology where he studied Akan and Sociology for his first degree with formal education in music under the tutelage of Dr Daniel Amponsah a.k.a. Agya Koo Nimo. Agya Koo Nimo taught him Classical Guitar and Philosophy in African Music. Subsequently, he enrolled at the University of Ghana and graduated in 2016 with a master's degree in Strategic Marketing.

He is also an associate co-opted member of the Chartered Institute of Marketing Ghana in recognition of his professional use of marketing in creative arts.

In March 2024, Kwame and his wife, Annica Nsia-Apau, graduated from the Institute of Paralegal Training and Leadership Studies (IPSL) with professional Master’s degrees in Alternative Dispute Resolution. This marks the second Master’s degree Kwame has earned.

In 1997, he achieved notoriety as a member of the "Akyeame" hiplife duo, together with fellow Ghanaian Daniel Kofi Amoateng (under the stage name Okyeame Kofi). They recorded together the albums, "Nyansapo" ("Witty Knot", 1997), "Nkonsonkonson" ("Shackles", 1998), "Ntoaso" ("Continuity", 2000) and "Apam Foforo" ("New Testament", 2002). He performed a solo under his own record label "One Mic Entertainment", since they parted in 2004. He also featured some renowned Ghanaian highlife and hiplife artists like Daddy Lumba, Kojo Antwi and Ofori Amponsah.

For declaring himself B.R.A (Best Rapper Alive) in a song he recorded after winning Ghana Music Awards Artist of the Year award in 2009, Okyeame Kwame sparked a conflict with fellow Ghanaian rapper Obrafour, who saw himself more deserving. This resulted in one of the most memorable feuds the Ghanaian music scene has seen, with Obrafour challenging Okyeame Kwame to a rap battle on the streets which was never honored. In 2011, after Obrafour had apologized for his actions, Okyeame Kwame explained he declined Obrafour's challenge because there was no need for it at the time, as winning Artist of the Year was vindictive enough.

Okyeame Kwame has made significant contributions to education and scholarship promotion. His rap lyrics (which incorporate didactic themes, social consciousness and poetry) are being studied in some Ghanaian universities.