Operation Quintana Roo (Spanish: Operacion Quintana Roo) is an anti-drug trafficking military operation jointly conducted by the Mexican army and navy in the Mexican state of Quintana Roo. The operation began in early February 2009 after the death of former Brigadier General Mauro Enrique Tello Quiñónez and two other men.

On February 3, 2009. Outside of Cancun, retired Brigadier General Mauro Enrique Tello Quiñónez was killed after spending less than a day on his new job as a special drug-fighting consultant for the Benito Juarez mayor. His dead body was found inside a Toyota pickup truck along a highway that leads to Mérida. Quintana Roo state officials reported that along with the general two other bodies were inside the truck, the two bodies were identified as Lieutenant Julio Cesar Roman Zuniga, who was the general's aide, and the second victim was Juan Ramirez Sanchez, the general's driver and nephew of Benito Juarez municipality mayor Gregorio Sánchez Martínez.