In Greek mythology, Othreis (Ancient Greek: Ὀθρηΐς Othrēís means "of Mount Othrys") was a nymph who consorted with both Zeus and Apollo and became by them mother of Meliteus and Phagrus respectively.

When Meliteus was born, Othreis, in fear of Hera's wrath, exposed the child. The boy, however, was nurtured by bees and thus survived. He was soon found by his half-brother Phager, who was pasturing his sheep in the neighborhood. Impressed with the child being nurtured in such a marvelous way, as well as having reckoned a prophecy that told him to take care of his relative nourished by bees, Phager adopted and raised Meliteus. When Meliteus grew up, he founded the city Melite in Phthia.