Community hub
0 subscribers8 pages, 0 posts
Recent from talks
All channels
Be the first to start a discussion here.
Be the first to start a discussion here.
Be the first to start a discussion here.
Be the first to start a discussion here.
Contribute something
Welcome to the community hub built to collect knowledge and have discussions related to PS75.
Nothing was collected or created yet.
from Wikipedia
 | |
| Clinical data | |
|---|---|
| ATC code |
|
| Identifiers | |
| |
| CAS Number | |
| Chemical and physical data | |
| Formula | C15H11ClN2 |
| Molar mass | 254.72 g·mol−1 |
| 3D model (JSmol) | |
| |
PS75 is an experimental analgesic drug which acts as a functionally selective alpha-2A (α2A) adrenergic agonist, with a Ki of 8.2nM and an EC50 of 4.8nM at the α2A-adrenergic receptor. In animal studies it was found to produce analgesia but without the sedation typical of older drugs acting at this target such as dexmedetomidine. While PS75 itself is unlikely to be developed for medical use, the successful separation of analgesia from sedative effects makes it likely that related compounds may be developed as non-sedating, non-opioid analgesic medications.[1]
References
[edit]- ^ Fink EA, Xu J, Hübner H, Braz JM, Seemann P, Avet C, et al. (September 2022). "Structure-based discovery of nonopioid analgesics acting through the α2A-adrenergic receptor". Science. 377 (6614) eabn7065. doi:10.1126/science.abn7065. PMC 10360211. PMID 36173843.