Pamekasan (Madurese: Mekkasân) is a town and district which serves as the administrative center of Pamekasan Regency, East Java Province, Indonesia. It is located on the island of Madura, in an inland location towards the south coast of the island.

Pamekasan consists of 18 villages (Kelurahan or Desa) namely:

Nine of the above (indicated by asterisks) are classed as urban (kelurahan) and nine as rural (desa).

Pamekasan has a tropical savanna climate (Aw) with moderate to little rainfall from May to November and heavy rainfall from December to April.