Pamekasan Regency (Madurese: Kabhupatèn Mekkasân) is a regency (kabupaten) of the province of East Java, Indonesia. It is located on Madura Island approximately 120 kilometres (75 mi) east of Surabaya, the provincial capital. The regency covers an area of 792.30 square kilometres (305.91 sq mi), and at the 2010 census it had a population of 795,918 (an increase from 689,225 at the previous census in 2000); at the 2020 census the total was 850,057 and the official estimate as at mid 2024 was 904,965 – comprising 442,986 males and 461,979 females. The administrative capital is the town of Pamekasan.

Pamekasan Regency is bordered on the east by Sumenep Regency, on the north by the Java Sea, on the west by Sampang Regency, and the south by the Madura Strait (separating Madura from the island of Java).

Pamekasan Regency consists of thirteen districts (kecamatan), tabulated below with their areas and their populations at the 2010 census and the 2020 census, together with the official estimates as at mid 2024. The table also includes the locations of the district administrative centres, the number of administrative villages in each district (totaling 178 rural desa and 11 urban kelurahan), and its postcode.

Notes: (a) including 2 kelurahan – Barurambat Timur and Lawangan Daya.
(b) comprising 9 kelurahan – see Pamekasan - (Kangenan, Patemon, Bugih, Jungcang Cang, Parteker, Barurambat Kota, Gladak Anyar, Kolpajung and Kowel) and 9 desa.

The population comprises Madurese, Javanese, and Chinese Indonesians.

One of the famous produces from this region is Batik Pamekasan.

Media related to Pamekasan Regency at Wikimedia Commons