Pankrushikhinsky District (Russian: Панкруши́хинский райо́н) is an administrative and municipal district (raion), one of the fifty-nine in Altai Krai, Russia. It is located in the northwest of the krai. The area of the district is 2,700 square kilometers (1,000 sq mi). Its administrative center is the rural locality (a selo) of Pankrushikha. Population: 13,364 (2010 census); 16,763 (2002 census); 17,591 (1989 Soviet census). The population of the administrative center accounts for 36.8% of the district's total population.

53°49′55″N 80°20′26″E / 53.83194°N 80.34056°E / 53.83194; 80.34056