Paraguayan Sign Language (Spanish: Lengua de señas paraguaya, LSPY), is the deaf sign language of Paraguay. It is not intelligible with neighboring languages, nor with American Sign Language, but speakers report that it has historical connections with Uruguayan Sign Language. It developed outside the schools, and was only used in education in 2009.

Paraguay is notably a bilingual country, where both Spanish and Guarani are spoken. The Language Law No. 4251 provides for fingerspelling adequate to both languages.