Perfluorocyclohexane or dodecafluorocyclohexane is a chemical which belongs to the class of fluorocarbons, sometimes referred to as perfluorocarbons or PFCs. Fluorocarbons and their derivatives are useful fluoropolymers, refrigerants, solvents, and anesthetics.

Perfluorocyclohexane can be synthesized by fluorination of cyclohexane.

Perfluorocyclohexane is chemically inert and thermally stable. It is a relatively non-toxic, clear, waxy solid, which has a high vapor pressure and therefore sublimes readily at room temperature.^{[citation needed]}

The molecule predominantly exists in its chair conformation, in which it possesses D_3d molecular symmetry.