Pontiac's War (also known as Pontiac's Conspiracy or Pontiac's Rebellion) was launched in 1763 by a confederation of Native Americans who were dissatisfied with British rule in the Great Lakes region following the French and Indian War (1754–1763). Warriors from numerous nations joined in an effort to drive British soldiers and settlers out of the region. The war is named after Odawa leader Pontiac, the most prominent of many Indigenous leaders in the conflict.

The war began in May 1763 when Native Americans, alarmed by policies imposed by British General Jeffery Amherst, attacked a number of British forts and settlements. Nine forts were destroyed, and hundreds of colonists were killed or captured, with many more fleeing the region. Hostilities came to an end after successful British Army expeditions in 1764 led to peace negotiations over the next two years. The Natives were unable to drive away the British, but the uprising prompted the British government to modify the policies that had provoked the conflict.

Warfare on the North American frontier was brutal; the killing of prisoners, the targeting of civilians, and other atrocities were widespread. The ruthlessness of the conflict was a reflection of a growing racial divide between indigenous peoples and British colonists. The British government sought to prevent further racial violence by issuing the Royal Proclamation of 1763, which created a boundary between colonists and Natives.

The conflict is named after its most well-known participant, the Ottawa leader Pontiac. An early name for the war was the "Giyasuta and Pontiac War", "Giyasuta" being an alternate spelling for Guyasuta, an influential Seneca/Mingo leader. The war became widely known as "Pontiac's Conspiracy" after the 1851 publication of Francis Parkman's The Conspiracy of Pontiac. Parkman's book was the definitive account of the war for nearly a century and is still in print.

In the 20th century, some historians argued that Parkman exaggerated the extent of Pontiac's influence in the conflict, so it was misleading to name the war after him. Francis Jennings (1988) wrote that "Pontiac was only a local Ottawa war chief in a 'resistance' involving many tribes." Alternate titles for the war have been proposed, such as "Pontiac's War for Indian Independence", the "Western Indians' Defensive War" and "The Amerindian War of 1763". Historians generally continue to use "Pontiac's War" or "Pontiac's Rebellion", with some 21st-century scholars arguing that Pontiac's importance was underestimated by 20th-century historians.

You think yourselves Masters of this Country, because you have taken it from the French, who, you know, had no Right to it, as it is the Property of us Indians.

In the decades before Pontiac's War, France and Great Britain participated in a series of wars in Europe that involved the French and Indian Wars in North America. The largest of these wars was the worldwide Seven Years' War, in which France lost New France in North America to Great Britain. Most fighting in the North American theater of the war, generally called the French and Indian War in the United States, or the War of Conquest (French: Guerre de la Conquête) in French Canada, came to an end after British General Jeffery Amherst captured French Montréal in 1760.

British troops occupied forts in the Ohio Country and Great Lakes region previously garrisoned by the French. Even before the war officially ended with the Treaty of Paris (1763), the British Crown began to implement policy changes to administer its vastly expanded American territory. The French had long cultivated alliances amongst Indigenous nations; by contrast, the British post-war approach essentially treated the nations as conquered peoples. Before long, Native Americans found themselves dissatisfied with the British occupation.