Poole Lifeboat Station is the base for Royal National Lifeboat Institution (RNLI) search and rescue operations at Poole, Dorset in England. The first lifeboat was stationed at Poole Harbour in 1865 and the present station was opened in 1988.

Since November 2016 it has operated two inshore lifeboats, an Atlantic 85 and a D class.

The first boathouse was built in 1865 at Sandbanks by the narrow entrance to the large, natural Poole Harbour. This was remote from the house in Poole which meant that the crew had to be collected by horse-drawn coach from the Antelope Hotel in the High Street and taken to Sandbanks.

In 1882 a new boathouse was built on land leased from Poole Corporation on the Fisherman's Dock at the east end of Poole Quay. A dedicated slipway was built in front of the boathouse in 1897 as the public slipway was often blocked by other boats. In 1887 a flagstaff had been erected so that messages could be exchanged with Sandbanks. At this time the crew was summoned to launches by a signal rocket. In 1892 this was changed to a signal mortar but this reverted to rockets in 1914 as the mortar being discharged could be mistaken for an explosion at the nearby gas works.

The last 'pulling and sailing' lifeboat at Poole, Harmar (ON 608), was withdrawn in 1939. It was replaced by a Surf motor lifeboat, Thomas Kirk Wright (ON 811). On 30 May 1940, Thomas Kirk Wright sailed to Dunkirk as one of boats summoned for Operation Dynamo, and was the first of 19 lifeboats to arrive there. It was crewed by the Royal Navy but was damaged by enemy fire. After repairs, a second trip across the channel was made on 2 June 1940, before eventually returning to normal duties at Poole.

An inflatable Inshore Rescue Boat was placed on station in 1964 but withdrawn in 1970, although by this time a 'Dell Quay Dory' was also in use. After a succession of 'rigid' lifeboats, the last one, a Boston Whaler Outrage, Sam and Iris Coles (A-513), was withdrawn from service in 1994, replaced initially by a B-class (Atlantic 21) Rigid inflatable boat, and a new B-class (Atlantic 75) Inshore lifeboat in 1995.

The boathouse at Fisherman's Dock was closed in 1974 and a new station opened with the Poole Harbour Yacht Club at Lilliput Marina. Another move came in 1989 when the lifeboat was moved back to Poole Quay, but this time at the west end beneath Poole Bridge. The following year new crew facilities and storerooms were constructed by adding a two-storey extension to the police office on Poole Quay.

In 1994 a floating boathouse was placed next to the lifeboat mooring for the new ILB that took up service at Poole the following year.