A Pressurized Mating Adapter (PMA) is a component used on the International Space Station (ISS) to convert the Common Berthing Mechanism (CBM) interface used to connect ISS modules to an APAS-95 spacecraft docking port. Three PMAs are attached to the US Orbital Segment of ISS. PMA-1 and PMA-2 were launched along with the Unity module in 1998 aboard STS-88; PMA-3 was launched in 2000 aboard STS-92. PMA-1 permanently connects the Unity and Zarya modules. International Docking Adapters were permanently installed on PMA-2 and PMA-3 in 2017 to convert them from the APAS-95 standard to the newer International Docking System Standard (IDSS).

Its origins lie in designs for the Pressurized Docking Mast, consisting of an off-axis frustoconical docking tunnel contained within a framework and a retractable coupling mechanism, later part of the Pressurized Berthing Adapter assembly that appeared in designs for Space Station Freedom 1987, and the reduced design referred to as 'Fred' 1991.

After 1992–1993 and the Russian integration into the International Space Station Alpha project, this NASA docking design abruptly disappeared from all concepts. This was due to the availability of Russian docking hardware and experience, brought together during the Shuttle–Mir program. Russian APAS docking technology originally planned for the then defunct Soviet space shuttle program was integrated into the US Space Shuttle ODS (Orbital/Orbiter Docking System). This could hard dock with the space station through a structural interface, which became the PMA. With both the Russian docking ring and the CBM integrated into the PMA, this became the link between the USOS and the ROS from 1993.

Fabrication completed in 1995 with tests and mating tests with Node STA throughout 1996–97.

The three PMAs are identical, but they have slightly different uses. All three perform the same basic function of connecting a CBM port of an ISS module to an APAS-95 docking port of another module or visiting spacecraft. For this purpose, the PMAs carry a passive CBM port and a passive APAS port. The PMAs are pressurized and heated from the inside, and they allow for power and data communications transfer through docking rings and external connections.

This was one of the first components of the ISS (International Space Station). PMA-1 joins the Russian side of the station with the US side. On STS-88, the crew used the shuttle's robotic arm to attach the Zarya control module to PMA-1, which was already connected to the aft berthing port of Unity. These first two station components are permanently connected by PMA-1.

PMA-2 is mounted on the forward port of the Harmony connecting node, and was used when Space Shuttle orbiters docked at the ISS. It was outfitted with Station-to-Shuttle Power Transfer System (SSPTS) hardware to allow the shuttles to stay docked longer to the space station.

PMA-2 was moved several times as part of the space station assembly process. It was originally connected to the forward hatch of Unity, but when STS-98 delivered the Destiny module in February 2001, PMA-2 was moved to the berthing ring of the Z1 truss so that Destiny could be berthed to the forward hatch of Unity. PMA-2 was then moved to the forward hatch of Destiny. (The removal of PMA-2 from Unity was the first time the CBM had been used to disconnect two ISS components.) After STS-120 had delivered Harmony to the space station in October 2007, Canadarm2 repositioned PMA-2 at the forward port of Harmony on November 12, 2007. Two days later, the combined package of Harmony and PMA-2 was moved to its final location, the forward hatch of Destiny. On July 18, 2016, International Docking Adapter-2 was launched on SpaceX CRS-9. It was attached and permanently connected to the APAS-95 port of PMA-2 during a spacewalk on August 19, 2016. As of 2020, PMA-2 is expected to stay berthed at the forward port of Harmony with the IDA connected for the remaining duration of the ISS.