Progress MS-15 (Russian: Прогресс МC-15), Russian production No. 444, identified by NASA as Progress 76P, was a Progress spaceflight operated by Roscosmos to resupply the International Space Station (ISS). This was the 167th flight of a Progress spacecraft.

The Progress-MS is an uncrewed freighter based on the Progress-M featuring improved avionics. This improved variant first launched on 21 December 2015. It has the following improvements:

A Soyuz-2.1a launch vehicle was used to launch Progress MS-15 to the International Space Station. Progress MS-15 was launched at 14:26:21 UTC from Baikonur Cosmodrome Site 31 on a fast-track trajectory. Following a nominal launch, Progress MS-15 docked with the Pirs port on the ISS two orbits later at 17:45:00 UTC.

Around 3 hours 20 minutes after the launch, Progress MS-15 successfully docked automatically at the nadir port of the Pirs module at 17:45:00 UTC, where it remained until February 2021. After its mission was completed, Progress MS-15 departed and re-entered the Earth's atmosphere for destruction over the South Pacific Ocean.

The Progress MS-15 spacecraft delivered 2,540 kg (5,600 lb) of cargo, with 1,430 kg (3,150 lb) of this being dry cargo. The following is a breakdown of cargo bound for the ISS:

The Progress MS-15 remained docked at the station through on 9 February 2021, when it departed with trash and re-entered the Earth's atmosphere for destruction over the South Pacific Ocean. The Pirs module, originally scheduled to be removed and discarded at the end of this mission, will stay attached to the station until the arrival of the Nauka module.