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Psilocybin mushroom
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Psilocybin mushroom
Psilocybin mushrooms, or psilocybin-containing mushrooms, commonly known as magic mushrooms or as shrooms, are a type of hallucinogenic mushroom and a polyphyletic informal group of fungi that contain the prodrug psilocybin, which turns into the psychedelic psilocin upon ingestion. The most potent species are members of genus Psilocybe, such as P. azurescens, P. semilanceata, and P. cyanescens, but psilocybin has also been isolated from approximately a dozen other genera, including Panaeolus (including Copelandia), Inocybe, Pluteus, Gymnopilus, and Pholiotina.
Amongst other cultural applications, psilocybin mushrooms are used as recreational drugs. Psilocybin mushrooms were used ritualistically in pre-Columbian Mexico, but claims of their widespread ancient use are largely exaggerated and shaped by modern idealization and ideology.
Psilocybe cubensis grows naturally in tropical and subtropical conditions, often near cattle due to the ideal conditions they provide for the growth of the fungus. The cow usually consumes grains or grass covered with the spores of P. cubensis, and the fungus will begin to germinate within the dung.[citation needed]
In a 2000 review on the worldwide distribution of psilocybin mushrooms, Gastón Guzmán and colleagues considered these distributed among the following genera: Psilocybe (116 species), Gymnopilus (14), Panaeolus (13), Copelandia (12), Pluteus (6) Inocybe (6), Pholiotina (4) and Galerina (1). Guzmán increased his estimate of the number of psilocybin-containing Psilocybe to 144 species in a 2005 review.
Many of them are found in Mexico (53 species), with the remainder distributed throughout Canada and the US (22), Europe (16), Asia (15), Africa (4), and Australia and associated islands (19). Generally, psilocybin-containing species are dark-spored, gilled mushrooms that grow in meadows and woods in the subtropics and tropics, usually in soils rich in humus and plant debris. Psilocybin mushrooms occur on all continents, but the majority of species are found in subtropical humid forests. P. cubensis is the most common Psilocybe in tropical areas. P. semilanceata, considered the world's most widely distributed psilocybin mushroom, is found in temperate parts of Europe, North America, Asia, South America, Australia and New Zealand, although it is absent from Mexico. In 2023, two new Psilocybe species (Hymenogastraceae), P. ingeli and P. maluti, were described from southern Africa.
Some bolete mushrooms, which are not closely related to any known psilocybin-containing mushroom species, have been reported to be hallucinogenic mushrooms, for instance in the Yunnan province in China. The exact species as well specific active compounds in these mushrooms are not known, although unidentified indolic compounds were detected by Albert Hofmann in some boletes such as Boletus manicus.
Magic mushroom composition varies from genus to genus and species to species. Its principal component is psilocybin, which is converted into psilocin to produce psychoactive effects. Besides psilocin, norpsilocin, baeocystin, norbaeocystin, and aeruginascin may also be present, which might result in an entourage effect and modify the effects of magic mushrooms. Animal studies suggest that the effects of pure psilocybin or psilocin and psilocybin mushrooms may be different and support the possibility of such an entourage effect with psilocybin mushrooms. Panaeolus subbalteatus, one species of magic mushroom, had the highest amount of psilocybin compared to the rest of the fruiting body.
Certain mushrooms are found to produce β-carbolines, such as harmine, harmane, tetrahydroharmine (THH), and harmaline, which inhibit monoamine oxidase (MAO), an enzyme that breaks down tryptamine alkaloids, and have other actions. They occur in different genera, such as Psilocybe, Cyclocybe, and Hygrophorus. Harmine, harmane, norharmane, and a range of other β-carbolines were discovered in Psilocybe species. β-Carbolines in psilocybin mushrooms may inhibit the metabolism of psilocybin and other constituents and thereby potentiate their effects.
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Psilocybin mushroom
Psilocybin mushrooms, or psilocybin-containing mushrooms, commonly known as magic mushrooms or as shrooms, are a type of hallucinogenic mushroom and a polyphyletic informal group of fungi that contain the prodrug psilocybin, which turns into the psychedelic psilocin upon ingestion. The most potent species are members of genus Psilocybe, such as P. azurescens, P. semilanceata, and P. cyanescens, but psilocybin has also been isolated from approximately a dozen other genera, including Panaeolus (including Copelandia), Inocybe, Pluteus, Gymnopilus, and Pholiotina.
Amongst other cultural applications, psilocybin mushrooms are used as recreational drugs. Psilocybin mushrooms were used ritualistically in pre-Columbian Mexico, but claims of their widespread ancient use are largely exaggerated and shaped by modern idealization and ideology.
Psilocybe cubensis grows naturally in tropical and subtropical conditions, often near cattle due to the ideal conditions they provide for the growth of the fungus. The cow usually consumes grains or grass covered with the spores of P. cubensis, and the fungus will begin to germinate within the dung.[citation needed]
In a 2000 review on the worldwide distribution of psilocybin mushrooms, Gastón Guzmán and colleagues considered these distributed among the following genera: Psilocybe (116 species), Gymnopilus (14), Panaeolus (13), Copelandia (12), Pluteus (6) Inocybe (6), Pholiotina (4) and Galerina (1). Guzmán increased his estimate of the number of psilocybin-containing Psilocybe to 144 species in a 2005 review.
Many of them are found in Mexico (53 species), with the remainder distributed throughout Canada and the US (22), Europe (16), Asia (15), Africa (4), and Australia and associated islands (19). Generally, psilocybin-containing species are dark-spored, gilled mushrooms that grow in meadows and woods in the subtropics and tropics, usually in soils rich in humus and plant debris. Psilocybin mushrooms occur on all continents, but the majority of species are found in subtropical humid forests. P. cubensis is the most common Psilocybe in tropical areas. P. semilanceata, considered the world's most widely distributed psilocybin mushroom, is found in temperate parts of Europe, North America, Asia, South America, Australia and New Zealand, although it is absent from Mexico. In 2023, two new Psilocybe species (Hymenogastraceae), P. ingeli and P. maluti, were described from southern Africa.
Some bolete mushrooms, which are not closely related to any known psilocybin-containing mushroom species, have been reported to be hallucinogenic mushrooms, for instance in the Yunnan province in China. The exact species as well specific active compounds in these mushrooms are not known, although unidentified indolic compounds were detected by Albert Hofmann in some boletes such as Boletus manicus.
Magic mushroom composition varies from genus to genus and species to species. Its principal component is psilocybin, which is converted into psilocin to produce psychoactive effects. Besides psilocin, norpsilocin, baeocystin, norbaeocystin, and aeruginascin may also be present, which might result in an entourage effect and modify the effects of magic mushrooms. Animal studies suggest that the effects of pure psilocybin or psilocin and psilocybin mushrooms may be different and support the possibility of such an entourage effect with psilocybin mushrooms. Panaeolus subbalteatus, one species of magic mushroom, had the highest amount of psilocybin compared to the rest of the fruiting body.
Certain mushrooms are found to produce β-carbolines, such as harmine, harmane, tetrahydroharmine (THH), and harmaline, which inhibit monoamine oxidase (MAO), an enzyme that breaks down tryptamine alkaloids, and have other actions. They occur in different genera, such as Psilocybe, Cyclocybe, and Hygrophorus. Harmine, harmane, norharmane, and a range of other β-carbolines were discovered in Psilocybe species. β-Carbolines in psilocybin mushrooms may inhibit the metabolism of psilocybin and other constituents and thereby potentiate their effects.
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