In pharmacology, a psycholeptic is a medication which produces a calming effect upon a person. Such medications include barbiturates, benzodiazepines, nonbenzodiazepines, phenothiazines, opiates/opioids, carbamates, ethanol, 2-methyl-2-butanol, GHB, cannabinoids (in some classifications), some antidepressants, neuroleptics, and some anticonvulsants. Many herbal medicines may also be classified as psycholeptics (e.g. kava).^{[citation needed]}

The psycholeptics are classified under N05 in the Anatomical Therapeutic Chemical Classification System.