Weisz made her television debut in the BBC television film 'Advocates II'. This marked the beginning of her professional acting career, giving her exposure to the industry and valuable on-set experience.

She appeared in an episode of the popular British detective drama 'Inspector Morse'. Although a small role, it contributed to building her resume and visibility within the British television landscape.

Weisz made her stage debut in Noël Coward's 'Design for Living' at the Gielgud Theatre. This critically acclaimed production provided her with a platform to showcase her acting abilities to a wider audience.

Weisz made her film debut in the low-budget science fiction horror film 'Death Machine'. While not a major role, it gave her experience working on a film set and marked her transition to the big screen.

Weisz gained wider recognition with her role in Bernardo Bertolucci's 'Stealing Beauty'. This film, although controversial, brought her international attention and helped establish her as a rising star.

Throughout the late 1990s, Weisz appeared in a variety of films, including 'Chain Reaction' (1996), 'Swept from the Sea' (1997), and 'The Land Girls' (1998), gaining experience in different genres and working with established directors.