Rama is a point and click adventure game developed by the Dynamix subsidiary of publisher Sierra On-Line and released for MS-DOS and Windows in 1996 and Classic Mac OS in 1997. A PlayStation version was released in 1998 exclusively in Japan. The game is based upon Arthur C. Clarke's books Rendezvous with Rama and Rama II, combining elements of their plots with a story that sees the player assuming the role of a replacement crew member for an expedition to investigate an interstellar ship and uncover its mysteries.

The game was praised for its music, story, and alien creatures. Critics mentioned similarities to Myst. It is the second game that Clarke was involved in, following the 1984 interactive fiction game Rendezvous with Rama by Telarium. A sequel to Rama was planned, but not developed.

Rama is played from a first person perspective. Players can interact with objects, picking up items and examining them in their inventory, along with using them to solve puzzles. To assist in exploration, the player has a wrist-based computer system designed to receive communication from other characters, examine data files, and provide a map of locations. Players also receive help from a small android which acts as the equivalent of an interface element for examining objects.

Four years ago, a gigantic cylindrical object entered the Solar System. The International Space Agency (ISA) named it Rama and sent an expedition named "Newton Team" to investigate. They soon discovered that Rama is a hollow, rotating cylinder with enormous cities, populated by other alien species that have been collected during its travels: Myrmicats (seen in images but never encountered in the game), Avians, Octospiders. The "native" beings of Rama are the Biots (biological robots) constructed by the aliens who built Rama, and are a part of it.

As in many Myst-like adventure games, the player is an anonymous, silent protagonist—an astronaut who is assigned to replace the late Valeriy Borzov who died during the mission under mysterious conditions, as the introduction explains.

The player at first must investigate the area known as "the Plains" and find items that will help solve the logical/mathematical puzzles. Two Raman cities, nicknamed "London" and "Bangkok" by the expedition crew, will be visited in order to learn more about the species that accompany the astronauts. To proceed, the player must solve "complete with the shape which is logically missing" puzzles as well as mathematic exercises in the octal and hexadecimal number systems.

After the Plains have been explored (actually when the player has managed to reach and obtain all the useful inventory items), Rama changes towards an impact course with Earth and a special team inside the expedition (originally consisting of Heilmann, Borzov and O'Toole) proceeds to the "Project Trinity" and arms a bomb network to destroy Rama and its inhabitants. The player then proceeds to the "New York" island within the Cylindrical Sea which houses one of the bombs. While there, the player learns that Rama's course has diverted away from Earth and is no longer a risk, but the bombs have already been armed to explode in six hours. Unfortunately, O'Toole, who knows the code to disarm it, is lost, and during the six in-game hours, the player has to interpret the code and find the bomb in order to disarm it.

Many of the characters first appeared in the novel Rama II. Characters are portrayed by live actors. There are several hints throughout the game about the characters' relations that point to a secondary plot. There are also some characters who are never met but are referred to elsewhere in the game: