Remedios (Spanish pronunciation: [reˈmeðjos]), also known as San Juan de los Remedios, is a city and municipality located 5 km (3 mi) from the northern coast of Cuba, in the center of the island. It is the oldest Spanish settlement in the former Las Villas province. It is now part of the province of Villa Clara.

It was declared a City by Isabella II of Spain, when the island was still a colony. Remedios is known as the Cradle of the Parrandas, possibly the Caribbean's largest and oldest traditional festival. Its patrons are John the Baptist and the Virgin of the Buenviaje.

Remedios is located about 4 hours by bus from Havana, and around 50 minutes from Santa Clara. It is less than an hour from here to beach resorts in the Santa María – Las Brujas cays, both situated north of the province. The municipality is bordered on the north by Caibarién, to the south by Camajuaní and Placetas, and to the east by Yaguajay (in Sancti Spíritus Province). Remedios has 10 consejos populares which include: El Carmén, San Salvador, and Hermanos Herrada, in the city of Remedios and nearby settlements, and Heriberto Duquesne, Buena Vista, General Carrillo, Zulueta, Tahón-Francisco Pérez, Remate de Ariosa, and Circunscripciónes Directas (Chiquito Fabregat or San Agustín).

This is recognized as the eighth-oldest European city in Cuba, but its real date of foundation has been obscured over time. It may be the second Spanish settlement on the island. Historians place the foundation date sometime between 1513 and 1524 by Spanish nobleman Vasco Porcallo de Figueroa. He was said to found the settlement on 13 April 1514. Documents reflect that this settlement had been preceded on the island only by Baracoa (1511) and Bayamo (1512).

Some believe that it was founded before Trinidad (1514). According to legend, Vasco, in order to avoid tax payments to the Crown, kept the village hidden from the knowledge of the King of Spain as long as he could. But the settlement grew and had to be recognized. Through his wife, the daughter of the Cacique of Sabaneque, Vasco received a huge land grant as a personal fief from Governor Diego Velázquez de Cuéllar, as stipulated by Spanish law. There was no municipal entity to govern the town. Upon Vasco's death in Puerto Principe in 1550, the town obtained its charter.

It was originally called Santa Cruz de la Sabana. Other names were Santa Cruz de Vasco Porcallo, Santa Cruz de la Sabana del Cayo, and lastly, by 1578, San Juan de los Remedios de la Sabana del Cayo. In the 16th, 17th and 18th centuries, land grants provided by the Crown to colonists allowed for a stable population settlement. The economic growth relied on agriculture and cattle raising, and this eventually became one of the major beef suppliers to Spain's Florida colonies.

By 1678 the demarcation between Remedios and Sancti Spiritus was established. Along with cattle raising, the sugar cane industry was developed, dependent on slave labor. By the end of the 17th and beginning of the 18th century, the cultivation of tobacco, coffee and cacao as commodity crops was also underway.

In 1682 (1672?), a major dispute arose among the settlers, led by Father Gonzalez de la Cruz, who claimed that satanic forces had taken hold of the place. The Spanish Crown sent a Royal Decree dated 29 January 1684 transferring the settlement to another place in order to avoid the demons. Eighteen families left the town and on 15 July 1689 established the village of Santa Clara. Today this is an important city in the center of Cuba and the capital of the province of Villa Clara.